Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effect of Panax notoginseng on Nitric Oxide Synthase, Cyclo-oxygenase-2 and Neutrophil Functions

  • Park, Soon-Gi (Department of AM-Pointology, Diagnostics and Cardiovascular Medical Research Center) ;
  • Joo, Shin-Tak (Department of AM-Pointology, Diagnostics and Cardiovascular Medical Research Center) ;
  • Ban, Chang-Gyu (Department of AM-Pointology, Diagnostics and Cardiovascular Medical Research Center) ;
  • Moon, Jin-Young (Department of AM-Pointology, Diagnostics and Cardiovascular Medical Research Center) ;
  • Park, Sun-Dong (Department of Prescription, College of Korean Medicne, Dongguk University) ;
  • Park, Won-Hwan (Department of AM-Pointology, Diagnostics and Cardiovascular Medical Research Center)
  • Published : 2006.10.25
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Abstract

Our preliminary aim is to elucidate the pharmacokinetic features of the PNS(Panax notoginseng Buck F.H. Chen. (Arialiaceae) root). First, we assessed the prevention of neurtrophil functions. A Panax notoginseng inhibited neutrophil functions, including degranulation, superoxide generation, and leukotriene B4 production, without any effect on 5-lipoxygenase activity. This Panax notoginseng reduced nitric oxide (NO) and prostaglandin E2 production in mouse peritoneal macrophages stimulated with lipopolysaccharide, whereas no influence on the activity of inducible NO synthase, cyclo-oxygenase-2 or cyclo-oxygenase-1 was observed. Panax notoginseng significantly reduced mouse paw oedema induced by carrageenan. The results indicate that Panax notoginseng exerts anti-inflammatory effects related to the inhibition of neutrophil functions and of NO and prostaglandin E2 production, which could be due to a decreased expression of inducible NO synthase and cyclo-oxygenase-2.

Keywords

References

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