Annals of Clinical Neurophysiology
- Volume 8 Issue 2
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- Pages.196-198
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- 2006
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- 2508-691X(pISSN)
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- 2508-6960(eISSN)
A Case of Antisynthetase Syndrome
항 Synthetase 증후군 1예
- Kim, Min-Jeong (Department of Neurology, Busan Paik Hospital, Inje University College of Medicine) ;
- Kim, Min Ah (Department of Neurology, Busan Paik Hospital, Inje University College of Medicine) ;
- Kim, Eung-Gyu (Department of Neurology, Busan Paik Hospital, Inje University College of Medicine) ;
- Kim, Chan-Hwan (Department of Pathology, Busan Paik Hospital, Inje University College of Medicine) ;
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Kim, Sang-Jin
(Department of Neurology, Busan Paik Hospital, Inje University College of Medicine)
- 김민정 (인제대학교 의과대학 부산백병원 신경과) ;
- 김민아 (인제대학교 의과대학 부산백병원 신경과) ;
- 김응규 (인제대학교 의과대학 부산백병원 신경과) ;
- 김찬환 (인제대학교 의과대학 부산백병원 병리과) ;
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김상진
(인제대학교 의과대학 부산백병원 신경과)
- Published : 2006.12.30
Abstract
It has been reported that antisynthetase syndrome belongs to the idiopathic myositis group which includes pulmonary interstitial disease, arthritis, Raynaud's phenomenon, and mechanic's hand, associated with the anti-Jo1 antibody. A 60- year-old man presented with one month history of lower limbs weakness, rapidly progressive exertional dyspnea, and arthralgia. A markedly increased titers of anti-Jo1 antibodies were found. Chest CT showed idiopathic pulmonary fibrosis. Muscle biopsies were consistent with polymyositis. A high dose corticosteroids and cyclosporine were not effective. We report a case of antisynthetase syndrome, in which immunosuppressive agents could not rescue the deteriorating disease course.