Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-allodynic effect of bee venom on neuropathic pain in the rat

  • Lee, Bae-Hwan (Department of Physiology, Brain Research Institute, Yonsei University College of Medicine) ;
  • Chae, Youn-Byoung (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hwang, Hye-Jeong (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Choi, Young-Kook (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Hahm, Dae-Hyun (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Han, Seung-Moo (Department of Biomedical Engineering, Kyung Hee University) ;
  • Kang, Sung-Keel (Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Hye-Jung (Graduate School of East-West Medicine, Institute of Oriental Medicine, Kyung Hee University) ;
  • Pyun, Kwang-Ho (Department of Integrative Medicine, College of Medicine, Catholic University) ;
  • Shim, In-Sop (Department of Integrative Medicine, College of Medicine, Catholic University of Korea)
  • Published : 2006.12.31
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Abstract

Neuropathic pain syndromes resulted from peripheral nerve injury appear to be resistant to conventional analgesics like opioids. However, it has been demonstrated that acupuncture including aqua-acupuncture may be effective in managing neuropathic pain. The present study was conducted to determine if bee venom injection into acupoint ihibits neuropathic pain, which is difficult to be treated by usual analgesics. Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery. Two weeks after nerve injury, mechanical and cold allodynia were tested in order to evaluate the antiallodynic effects of bee venom injection into an acupoint. Intraperitoneal injection of morphine inhibited mechanical allodynia dose-dependently. Bee venom injected into Zusanli acupoint significantly inhibited mechanical and cold allodynia. These results suggest that bee venom-acupuncture as well as morphine is very effective to inhibit mechanical allodynia.

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References

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