Advances in Traditional Medicine

  • 제6권4호
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  • Pages.344-348
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  • 2006
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Antinociceptive and sedative effects of the bark of Cerbera odollam Gaertn.

  • 발행 : 2006.12.31
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초록

The crude methanolic extract of the bark of Cerbera odollam Gaertn. was evaluated for its possible antinociceptive and neuropharmacological activities in animal models. At the dose of 250 and 500 mg/kg body weight, the extract showed a significant antinociceptive effect in acetic acid induced writhing in mice comparable to that produced by aspirin, used as standard drug (P<0.001). The extract significantly reduced the time of onset of sleep (P<0.01) and potentiated the pentobarbital induced sleeping time in mice at the dose of 400 mg/kg of body weight significantly (P<0.001). It also decreased the open field score in open field test significantly at the dose of 400 mg/kg of body weight (P < 0.05). The obtained results tend to suggest the probable antinociceptive and neuropharmacological activities of the crude extract.

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참고문헌

  1. Ahmed F, Selim MST, Das AK, Choudhuri MSK. (2004) Anti-inflammatory and antinociceptive activities of Lippia nodiflora Linn. Pharmazie 59, 329-333.
  2. Bowman WC, Rand MJ. (1980) Text Book of Pharmacology, 2nd edn. Black Well Scientific Publications, New York, 21-23.
  3. Capasso A, Aquino R, De Simone F, Sorrentino L. (1996) Neuropharmacological effects of extracts from Sickingia williamsii. J. Pharm. Pharmacol. 48, 592-595.
  4. Chen JS, Zheng S. (1987) Poisonous plants of China, p. 75, Science press, Beijing.
  5. Derardt R, Jougney S, Delevalcee F, Falhout M. (1980) Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur. J. Pharmacol. 51, 17-24.
  6. Evans WC. (1989) Trease and Evan’s Text book of Pharmacognosy, 13th ed., p. 546, Cambridge University Press, London.
  7. Gupta BD, Dandiya PC, Gupta M. (1971) A psychopharmacological analysis of behavior in rat. Jpn. J. Pharmacol. 21, 293. https://doi.org/10.1254/jjp.21.293
  8. Hien TT, Navarro-Delmasure C, Vy T. (1991) Toxicity and effects on the central nervous system of a Cerbera odollam leaf extract. J. Ethnopharmacol. 34, 201-206. https://doi.org/10.1016/0378-8741(91)90038-F
  9. Iyer GV, Narendranath M. (1975) A preliminary report on the neurological manifestation of Cerbera odollam poisoning. Indian J. Med. Res. 63, 312-314.
  10. Kini PM, Pai KN. (1965) Cardiotoxic effects of Cerbera odollam. Indian Heart J. 17, 263-270.
  11. Kirtikar KR, Basu BD. (1987) Indian Medicinal Plants, Vol. III, 2nd ed., pp. 1552-1553. International Book Distributors, India.
  12. Laphookhieo S, Karakai CX, Chantrapromma K. (2004) Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochemistry 65, 507-510. https://doi.org/10.1016/j.phytochem.2003.10.019
  13. Perez GRM, Perez LJA, Garcia DLM, Sossa MH. (1998) Neuro-pharmacological activity of Solanum nigrum fruit. J. Ethnopharmacol. 62, 43-48. https://doi.org/10.1016/S0378-8741(98)00059-2
  14. Rollet B.(1981) Bibliography on mangroves research, 1600-1975. p. 479, UNESCO Paris, Information Retrieval Ltd., London.
  15. Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, Scheffer JJC. (2003) Antiinflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir. J. Ethnopharmacol. 84, 31-35. https://doi.org/10.1016/S0378-8741(02)00264-7
  16. Yamauchi T, Abe F. (1987) Studies on Cerbera IV, polar cardenolide glycoside from the leaves of Cerbera odollam and Cerbera manghas. Chem. Pharm. Bull. 35, 4813-4818.
  17. Whittle BA. (1964) The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics. Br. J. Pharmacol. Chemother. 22, 246.
  18. Williamson EM, Okpako DT, Evans FJ. (1996) Pharmacological methods in phytotherapy research: Selection, preparation and pharmacological evaluation of plant material, Vol. 1, 1st ed., pp. 131-184, John Wiley &Sons Ltd., England.

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