Advances in Traditional Medicine

  • 제7권4호
  • /
  • Pages.363-371
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  • 2007
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Effect of Swietenia macrophylla seeds on normal and alloxan-induced diabetic rats

  • A, Maiti (Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University) ;
  • S, Dewanjee (Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University) ;
  • SC, Mandal (Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University)
  • 발행 : 2007.12.31
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초록

The methanol extract of the seed of Swietenia macrophylla (Meliaceae) seeds were investigated for its hypoglycaemic activity in normal and alloxan induced diabetic rats. Seed extract suspended in aqueous Tween 80 solution, the graded doses were administered to normal and experimental diabetic rats for 10 days. Fasting blood glucose levels, serum lipid profiles and changes in body weight were evaluated in normal rats while the hepatic marker enzymes and liver glycogen levels were evaluated additionally in diabetic rats. The diabetic groups treated with the seed extract were compared with standard drug glibenclamide. The findings showed the significant antidiabetic potential of the extract in ameliorating the diabetic conditions in diabetic rats. The extract also has hypoglycaemic action in normal rats. A toxicity study has been performed for the extract, which revealed that the extract is safe to use even at the doses of 3.2 mg/kg of body weight orally. The result from the present investigation indicates good correlation between the folk use and scientific investigation.

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참고문헌

  1. Bahijri S, Karim A, Karimullah. (1984) Antidiabetic drugs of vegetable origin, A general survey. J. Pharm. Pb. Univ. Lhr. 5, 37-41
  2. Balkau B, Charles MA, Eschwege E. (2000) Discussion epidemiologigue des nouveaux criteres du diabetes. Mt. Endocrionologie 2, 229-234
  3. Bhaskara Rao R, Murugesan T, Sinha S, Saha BP, Pal M, Mandal SC. (2002) Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats. Phytother. Res. 16, 590-592 https://doi.org/10.1002/ptr.988
  4. Bonner-weir S. (1988) Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans. Diabetes 37, 616-621 https://doi.org/10.2337/diabetes.37.5.616
  5. De Haro-Hernandez R, Cabrera-Munoz L, Mendez JD. (2004) Regeneration of beta cells and neogenesis from small ducts or acinar cells promote recovery of endocrine pancreatic function in alloxan-treated rats. Arch. Med. Res. 35, 114-120 https://doi.org/10.1016/j.arcmed.2003.10.001
  6. Dhanabal SP, Sureshkumar M, Ramanathan M, Suresh B. (2005) Hypoglycaemic effect of ethanolic extract of Musa sapientum on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential. J. Herb Pharmacother. 5, 7-19 https://doi.org/10.1300/J157v05n02_02
  7. Erah PO, Osuide GE, Omogbai EKI. (1996) Hypoglycaemic effect of the extract of Solenostemon monostachys leaves. J. West Afr. Pharm. 10, 21-27
  8. Ghosh MN. (1984) Toxicity Studies: Fundamentals of Experimental Pharmacology, 2nd ed. Scientific Book Agency, Kolkata, India, pp. 153-158
  9. Gilman AG, Goodman LS. (1985) The Pharmacological Basis for Therapeutics. Macmillan, New York, pp. 149-151
  10. Guevera AP, Apilado A, Sakarai H, Kozuka M, Tokunda H. (1996) Anti-inflammatory, antimutagenecity and antitumor activity of mahagony seeds Swietenia macrophylla (Meliaceae). Phill. J. Sc. 125, 271-278
  11. Guha Sircar SSG, Chakraborty T. (1951) Tetranortriterpenoid from Swietenia macrophylla. J. Ind. Chem. Soc. 28, 207
  12. Holman RR, Turner RC. (1991) Textbook of Diabetes. Blackwell, Oxford, UK, pp. 407-469
  13. Huang X, Vaag A, Hanson M, Weng J, Goop L. (2000) Impaired insulin stimulated expression of the glycogen synthase gene in skeletal muscle of Type-2 diabetic patients is aquired rather than inherited. J. Clin. Endo. Metab. 85, 1584-1590 https://doi.org/10.1210/jc.85.4.1584
  14. Jorns A, Munday R, Tiedge M, Lenzen S. (1997) Comparative toxicity of alloxan, N-alkyl-alloxans and ninhydrin to isolated pancreatic islets in vitro. J. Endocrinol. 155, 283-293 https://doi.org/10.1677/joe.0.1550283
  15. Kapeham, SM. (1997) Drugs from natural products-plant sources in drug discovery, Sciences and Development, Washington D C, American chemical society, pp. 6
  16. Krishnakumar K, Augusti KT, Vijammal Pl. (2000) Hypolipidemic effect of Salacia oblonga Wall. Root bark in streptozotocin diabetes rats. Med. Sci. 28, 65-67
  17. Kuyvenhoven JP, Meinders AE. (1999) Oxidative stress and diabetic mellitus pathogenesis of longterm complications. Eur. J. Interm. Med. 10, 9-19 https://doi.org/10.1016/S0953-6205(99)00009-6
  18. Mootoo BS, Allisha A, Motilal R, Pingal R, Ramlal A, Khan A, Reynolds WF, McLean S. (1999) Limonoids from Swietenia macrophylla and S. aubrevilleana. J. Nat. Prod. 62, 1514-1517 https://doi.org/10.1021/np990199x
  19. Nanda SA, Baskandy SAE, Negam SA. (1997) Evaluation of the hypoglycaemic activity of a traditional herbal preparation in male diabetics rats. Fitoterapia 68, 240-244
  20. Pepato MT, Baviera AM, Vendramini PC, Perez MP, Kettelnut IC, Brunett IL. (2003) Cissus sicyoides (Princess wine) in the long term treatment streptozitocin diabetes rats. Biotchnol. Appl. Biochem. 37, 15-20 https://doi.org/10.1042/BA20020065
  21. Rastogi RP, Mehrotra BN. (1990) Compendium of Indian Medicinal Plants. Vol. I, PID, New-Delhi, India, pp. 397
  22. Shigetoshi K, Lamik M, Tohru K, Hisao E. (1990) Constituents of the seeds of S. mahagony Jacq, isolation, structure and $^1H$ and $^{13}C$ NMR signal Assignments of new tetranor triterpenoids related to swietenin and swietenolide. Chem. Pharm. Bull. 38, 639-651
  23. Skim F, Kayya A, Jaouri JT, Lazrek HB. (1999) Hypoglycaemic activity of Globularia alypum leaves in rats. Fitoterapia 70, 382-389 https://doi.org/10.1016/S0367-326X(99)00058-1
  24. Szkudelski T. (2001) The mechanism of Alloxan and Streptozotocin action in b cells of the rat pancreas. Physiol. Res. 50, 537-546
  25. Turner MA. (1965) Screening methods in pharmacology, 2nd ed. Academic press. New York, pp. 26
  26. West IC. (2000) Radicals and oxidative stress in diabetes. Diabet. Med. 17, 171-180 https://doi.org/10.1046/j.1464-5491.2000.00259.x
  27. WHO. (1980) World Health Organization Expert Committee on Diabetes Mellitus, Second report, Technical report series, Geneva, 646
  28. Zarrow MX, Yochim JM, McCarthy JL. (1964) Experimental Endocrinology: A Source Book of Basic Techniques, Academic Press, New York, pp. 406-409