DOI QR코드

DOI QR Code

Antihyperglycemic activity of Biophytum sensitivum (L.) DC in alloxan diabetic rats

  • Mishra, Moumita (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Bandyopadhyay, Durba (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Pramanik, Kartick Chandra (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University) ;
  • Chatterjee, Tapan Kumar (Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University)
  • Published : 2007.12.31

Abstract

The study was to evaluate the antihyperglycemic activity of Biophytum sensitivum (L.) DC in different extracts. Albino Wistar rats with alloxan hydrate induced diabetes were divided into 7 groups of 6 each. Both aqueous and methanolic extract of Biophytum sensitivum were prepared and given individually at different doses to different batches of rats (both normal and diabetic rats) after an overnight fast. Methanolic extract at the dose of 200 mg/kg body weight showed maximum blood glucose lowering effect in diabetic rats. The same dosages did not produce any hypoglycemic activity in normal rats. The antihyperglycemic activity of Biophytum sensitivum was compared with a standard drug Glibenclamide, an oral hypoglycemic agent. The above results suggest that maximum hypoglycemic effect was found only with a dose of up to 200 mg/kg b.w. of methanolic extract which is therefore the optimum dose for hypoglycemia and was used in all the experiments of the present study.

Keywords

References

  1. Akhtar MS, Athar MA, Yaqub M. (1981) Effect of Momordica charantia on the blood glucose levels of normal and alloxan diabetic rabbits. Planta Med. 42, 205-212 https://doi.org/10.1055/s-2007-971629
  2. Anonymous. (2004) Medicinal and aromatic plants of red Laterite region of west Bengal (Bankura, Midnapur and Purulia), (ed.) S. C. Pakrasi and S. Mukhopadhyay. Joint Publication of West Bengal academy of Science and Technology, Dept. of Science and Technology (WB) and Dept. of Biotechnology (Gol), pp-56
  3. Bennett P H. (1994) Definition, Diagnosis and Classification of Diabetes Mellitus and Impaired Glucose Tolerance. In Joslin's Diabetes Mellitus (13th ed.) C.R. Khan and G.C.weir (eds.), Lea and Febiger, Philadelphia, p.193
  4. Chatterjee TK. (1993) Handbook on laboratory mice and rats. 1st ed Calcutta
  5. Ewart RBI, Kamfeld S, Kipnis DM. (1975) Effect of lectins on hormones release from isolated rat islets of langerhans. Diabetes 24, 705-714 https://doi.org/10.2337/diabetes.24.8.705
  6. Ghosh MN. (1984) Fundamentals of Experimental Pharmacology.2nd ed. Calcutta: Scientific Book Agency
  7. Holman RR, Turner RC. (1991) Oral agents and insulin in the treatment of NIDDM. In: Pickup, J., Williams, G. (Eds.), Text-book of Diabetes, Blackwell, Oxford, pp. 467-469
  8. Ivorra MD, Paya M, Villar A. (1989) A review of natural products and plants as potent antidiabetic drugs. J. Ethnopharmacol. 27, 243-276 https://doi.org/10.1016/0378-8741(89)90001-9
  9. Kameswara Rao B, Giri R, Kesavulu MM, Apparao Ch. (1997) Herbal medicine: In the management of diabetes mellitus, Manphar Vaidhya Patrika 1, 33-35
  10. Kameswara Rao B, Kesavulu MM, Apparao Ch. (2001) Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats. J. Ethnopharmacol. 78, 67-71 https://doi.org/10.1016/S0378-8741(01)00324-5
  11. Litchfield JT. (1959) Wilcoxon F. J. Pharmacol. Exp. Ther. 96, 99-113
  12. Mukherjee SK. (1981) Indigenous drugs in Diabetes mellitus, J. Diabetes Assoc. Ind. XXI, 97-106
  13. Oliver-Bever B. (1986) Oral hypoglycemic action. Medicinal plants in Tropical West Africa, Cambridge University Press, London, pp. 245-267
  14. Pourt TE. (1974) In: Malaisse, WJ. , Pirart, J., (Eds.), Processdings VIII Congress of International Diabetes Federation, excerpta Meica, Amsterdam, p.162
  15. Puri D. (2001) The Insulinotropic activity of a Nepalese Medicinal plant Biophytum sensitivum: preliminary experimental study. J. Ethnopharmacol. 78, 89-93 https://doi.org/10.1016/S0378-8741(01)00306-3
  16. Rai MK. (1995) A review on some antidiabetic plants of India, Ancient Sci. Life XIV, 42-54
  17. Rang HP, Dale MM, Ritter JM, Moore PK. (2003) 'Pharmacology' (5th edition) Elsevier Science Limited pp 386
  18. Williams G. (1994) Management of non-insulin dependent diabetes mellitus. Lancet 343, 95-100