DOI QR코드

DOI QR Code

Analgesic activity of the ethanolic extract of Aphanamixis polystachya bark

  • Hasan, Faizul (Pharmacy Discipline, Life Science School, Khulna University) ;
  • Rouf, Razina (Pharmacy Discipline, Life Science School, Khulna University) ;
  • Barua, Juwel (Pharmacy Discipline, Life Science School, Khulna University) ;
  • Uddin, Shaikh Jamal (Pharmacy Discipline, Life Science School, Khulna University) ;
  • Shilpi, Jamil Ahmad (Pharmacy Discipline, Life Science School, Khulna University)
  • 발행 : 2007.12.31

초록

Ethanolic extract of Aphanamixis polystachya bark was used to investigate its analgesic activity by acetic acid induced writhing in mice. The bark extract exhibited statistically significant and dose dependent analgesic activity in mice. The bark extract at the doses of 250 and 500 mg/kg body weight showed 40.69% and 62.07% writhing inhibition respectively in mice whereas diclofenac-Na produced 75.17% writhing inhibition as a positive control.

키워드

참고문헌

  1. Ghani A. (2003) Medicinal Plants of Bangladesh. Asiatic Society of Bangladesh, Dhaka
  2. Chatterjee A, Kundu AB, Chakraborty T, Chandrasekharan S. (1970) Tetrahedron. 26, 1859-1867 https://doi.org/10.1016/S0040-4020(01)92762-0
  3. Mulholand DA and Naidoo N. (1999) Phytochemistry 51, 927-930 https://doi.org/10.1016/S0031-9422(99)00157-0
  4. Rabi R and Gupta RC. (1995) Int. J. Pharmacognosy 33, 359
  5. Rabi T, Rmachandran C, Fonseca HB, Nair RP, Alamo A, Melnick SJ, Escalon E. (2003) Novel drug amooranin induces apoptosis through caspase activity in human breast carcinoma cell lines. Breast Cancer Res. Treat. 80, 321-330 https://doi.org/10.1023/A:1024911925623
  6. Rouf R, Uddin SJ, Shilpi JA, Alamgir M. (2007) Assessment of antidiarrhoeal activity of the methanolic extract of Xylocarpus granatum bark in mice model. J. Ethnopharmacol. 109, 539-542 https://doi.org/10.1016/j.jep.2006.08.015
  7. Rouf R, Uddin SJ, Shilpi JA, Rahman MT, Ferdous MM, Sarker SD. (2006) Evaluation of anti-diarrhoeal properties of Diospyros peregrina in the castor oil-induced diarrhoea model in mice. A. R. S. Pharmarmaceutica 47, 81-89
  8. Shilpi JA, Uddin SJ, Rouf R, Billah MM. (2004), Central nervous system depressant activity of Diospyros peregrina bark. Orient. Pharm. Exp. Med. 4, 249-252
  9. Uddin SJ, Shilpi JA, Rouf R, Ferdous MM, Nahar L, Sarker SD. (2006) Antinociceptive activity of some Bangladeshi Medicinal Plant extracts. Orient. Pharm. Exp. Med. 6, 96-101
  10. Uddin SJ, Shilpi JA, Alam SMS, Alamgir M, Rahman MT, Sarker SD. (2005) Antidiarrhoeal activity of the methanol extract of the barks of Xylocarpus molucensis in castor oil and magnesium sulphate-induced diarrhoea models in mice. J Ethnopharmacol. 101, 139-143 https://doi.org/10.1016/j.jep.2005.04.006
  11. Uddin SJ, Shilpi JA, Barua J, Rouf R. (2005) Antinociceptive activity of Ceriops decandra leaf and pneumatophore. Fitoterapia 76, 261-263 https://doi.org/10.1016/j.fitote.2004.12.015
  12. Uddin SJ, Shilpi JA, Delazar A, Nahar L, Sarker SD. (2004) Free radical scavenging activity of some Bangladeshi plant extracts. Orient. Pharm. Exp. Med. 4, 185-193