The Korean Journal of Pain

  • 제20권1호
  • /
  • Pages.15-20
  • /
  • 2007
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  • 2005-9159(pISSN)
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  • 2093-0569(eISSN)
대한통증학회 (The Korean Pain Society)
권호 표지

백서의 척추간 신경공 협착증 모델에서 Lipo-Prostaglandin E1의 정주효과

The Effect of Intravenous Lipo-Prostaglandin E1 Injectioin in a Rat Foraminal Stenosis Model

  • 윤혜경 (분당서울대학교병원 마취통증의학과) ;
  • 이평복 (분당서울대학교병원 마취통증의학과) ;
  • 한진수 (건국대학교 수의과대학 실험동물의학교실) ;
  • 박상현 (제주대학교병원 마취통증의학과) ;
  • 이승윤 (제주대학교병원 마취통증의학과) ;
  • 김양현 (분당서울대학교병원 마취통증의학과) ;
  • 김용철 (분당서울대학교병원 마취통증의학과) ;
  • 이상철 (분당서울대학교병원 마취통증의학과)
  • Yoon, Hye Kyoung (Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Pyung Bok (Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital) ;
  • Han, Jin Soo (Department of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University) ;
  • Park, Sang Hyun (Department of Anesthesiology and Pain Medicine, Cheju National University Hospital) ;
  • Lee, Seung Yoon (Department of Anesthesiology and Pain Medicine, Cheju National University Hospital) ;
  • Lee, Yang Hyun (Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Yong Chul (Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital) ;
  • Lee, Sang Chul (Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital)
  • 투고 : 2007.03.19
  • 심사 : 2007.06.11
  • 발행 : 2007.06.30
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초록

Background: Lipo-prostaglandin E1 (Lipo-$PGE_1$) has vasodilating and platelet aggregation inhibitory characteristics and it has been used as a treatment for patients with blood flow dysfunction disease. Based on the mechanisms of lumbar spinal stenosis, including veno congestion, neuro-ischemia and mechanical compression, we aimed to study whether intravenous Lipo-$PGE_1$ injection has any therapeutic effect on hyperalgesia in a rat foraminal stenosis model. Methods: In this study, twenty male Sprague-Dawley rats were divided into the control (n = 10) and Lipo-$PGE_1$ (n = 10) groups. A small stainless steel rod was inserted into the L5-6 intervertebral foramen to induce intervertebral foramen stenosis and chronic DRG compression. In the Lipo-$PGE_1$ group, $0.15{\mu}g/kg$ of Lipo-$PGE_1$ were injected intravenously via a tail vein for 10 days starting from the $3^{rd}$ day after operation. Behavioral testing for mechanical and thermal hyperalgesia was performed for 3 weeks after the injections. Results: From the $10^{th}$ day after Lipo-$PGE_1$ injection, the rats in the experimental group showed significant recovery of their mechanical threshold, and this effect was maintained for 3 weeks. No significant differences of the thermal hyperalgesia were observed between the two groups. Conclusions: These findings suggest that intravenously injected Lipo-$PGE_1$ may be effective for alleviating neuropathic pain, which isthe main symptom of spinal stenosis, by improving the blood flow dysfunction.

키워드

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