DOI QR코드

DOI QR Code

Changes in the Levels of Insulin-like Growth Factors (IGF-I and IGF-II) in Bovine Milk According to the Lactation Period and Parity

  • Kang, S.H. (Institute of Dairy Food Research, Seoul Dairy Cooperative) ;
  • Kim, J.U. (Division of Food Science, Korea University) ;
  • Kim, Y. (Division of Food Science, Korea University) ;
  • Han, K.S. (Division of Food Science, Korea University) ;
  • Lee, W.J. (Division of Animal Science and Technology, Gyeongsang National University) ;
  • Imm, J.Y. (Department of Food Science & Nutrition, Kookmin University) ;
  • Oh, S. (Department of Animal Science, Chonnam National University) ;
  • Park, D.J. (Korea Food Research Institute) ;
  • Moon, Y.I. (Department of Animal Health Management, Woosuk University) ;
  • Kim, S.H. (Division of Food Science, Korea University)
  • Received : 2006.02.16
  • Accepted : 2006.06.09
  • Published : 2007.01.01

Abstract

The objectives of this study were to characterize the changes occurring in the levels of insulin-like growth factors (IGF-I and IGF-II) in bovine milk during a one-year lactation period, and to determine the parameters affecting IGF content in bovine milk. Milk was collected individually from lactating Holstein cows (n=70), and IGF-I and -II levels were determined via radioimmunoassay, using 125I after acid-ethanol treatment. The proximate compositions of the milk samples were determined using a near-infrared milk analyzer. The data were analyzed by the GLM and CORR procedures using SAS software to determine significant differences (p<0.05) occurring within groups (dairy farms, lactation periods, season, and parity). We noted an approximately six-fold reduction in the IGF-I concentration (from 2,462.7 to 353.0 ng/ml) and a three-fold drop in the IGF-II concentration (from 929.1 to 365.7 ng/ml) in the bovine colostrum, between 6 h after parturition and 18 h after parturition. IGF-I and -II content, measured at the early, middle, and late stages of lactation did not change significantly throughout the entirety of the lactation period. Interestingly, parity did not significantly affect IGF-I content, but did significantly affect IGF-II content between the primiparous and multiparous cows. We also found there were no significant relationships between IGF-I and total protein content or somatic cell counts (p<0.05).

Keywords

References

  1. Campbell, P. G. and C. R. Baumrucker. 1989. Insulin-like growth factor-I and its association with binding proteins in bovine milk. J. Endocrinol. 120:21-29. https://doi.org/10.1677/joe.0.1200021
  2. Collier, R. J., M. A. Miller, J. R. Hildebrandt, A. R. Torkelson, T. C. White, K. S. Madsen, J. L. Vicini, P. J. Eppard and G. M. Lanza. 1991. Factors affecting insulin-like growth factor-I concentration in bovine milk. J. Dairy Sci. 74:2905-2911. https://doi.org/10.3168/jds.S0022-0302(91)78473-7
  3. Daxenberger, A., B. H. Breier and H. Sauerwein. 1998. Increased milk levels of insulin-like growth factor 1(IGF-1) for the identification of bovine somatotropin(bST) treated cows. Analyst. 123:2429-2435. https://doi.org/10.1039/a804923h
  4. Donovan, S. M., R. L. Hintz, D. M. Wilson and R. G. Rosenfeld. 1991. Insulin-Like Growth Factors I and II and Their Binding proteins in Rat Milk. Pediatric Research. 29:50-55. https://doi.org/10.1203/00006450-199101000-00010
  5. Donovan, S. M., L. K. McNeil, R. J. Flores and J. Odle. 1994. Insulin-Like Growth Factors and Insulin-Like Growth Factor Binding proteins in Porcine serum and Milk throughout Lactation. Pediatric Research. 36:159-168. https://doi.org/10.1203/00006450-199408000-00005
  6. Etherton, T. D., J. P. Wiggins, C. M. Evock, C. S. Chung, J. F. Rebhun, P. E. Walton and N. C. Steele. 1987. Stimulaton of pig growth performance by porcine growth hormone: Determination of the dose-response relationship. J. Anim. Sci. 64: 433-443. https://doi.org/10.2527/jas1987.642433x
  7. Faulkner, A. 1999. Changes in plasma and milk concentrations of glucose and IGF-I in response to exogenous growth hormone in lactating goats. J. Dairy Res. 66:207-214. https://doi.org/10.1017/S0022029999003441
  8. Francis, G. L., F. M. Upton, F. J. Ballard, K. A. McNeil and J. C. Wallace. 1988. Insulin-like growth factors I and II in bovine colostrum. Biochem. J. 251:95-103. https://doi.org/10.1042/bj2510095
  9. Holly, J. M. P. 1998. Editorial The IGF-II enigma. Growth Horm IGF Res. 8:183-184. https://doi.org/10.1016/S1096-6374(98)80109-3
  10. Kim, W. K., M. H. Kim, D. S. Seo, C. Y. Lee, Y. O. Suk, and Y. Ko. 2005. Associations between Feed Efficiency, Body Growth and Serum Insulin-like Growth Factor-I Level for Korean Native Ogol Chickens. Asian-Aust. J. Anim. Sci. 18:532-537. https://doi.org/10.5713/ajas.2005.532
  11. Lee, C. Y. and D. M. Henricks. 1990. Comparisons of various acidic treatments of bovine serum on insulin-like growth factor-I immunoreactivity and binding activity. J. Endocrinol. 127:139-148. https://doi.org/10.1677/joe.0.1270139
  12. Lee, C. Y., H. H. Head, C. R. Feinstein, J. Hayen and F. A. Simmen. 1995. Endocrine changes and circulating Insulin-like growth factors in newborn calves fed colostrum, milk or milk replacer. Asia-Aust. J. Anim. Sci. 8(1):51-58. https://doi.org/10.5713/ajas.1995.51
  13. Liebe, A. and D. Schams. 1998. Growth factors in milk: interrelationships with somatic cell count. J. Dairy Sci. 65:93-100.
  14. Mackle, T. R., D. A. Dwyer and D. E. Bauman. 2000. Intramammary infusion of insulin or insulin-like growth factor-I did not increase milk protein yield in dairy cows. J. Dairy Sci. 83:1740-1749. https://doi.org/10.3168/jds.S0022-0302(00)75044-2
  15. SAS Institute Inc. 1985. $SAS^{\circledR}$ User's Guide: Statistics, Version 5 Edition. Cary, NC: SAS Institute Inc.
  16. Vega, J. R., C. A. Gibson, T. C. Skaar, D. L. Hadsell and C. R. Baumrucker. 1991. Insulin-like growth factor (IGF)-I and -II and IGF binding proteins in serum and mammary secretions during the dry period and early lactation in dairy cows. J. Anim. Sci. 69:2538-2547. https://doi.org/10.2527/1991.6962538x

Cited by

  1. Effects of Litter Size and Parity Number on Mammary Secretions Including, Insulin-Like Growth Factor-1, Immunoglobulin G and Vitamin A of Black Bengal, Saanen and Their Crossbred Goats in Thailand vol.8, pp.6, 2007, https://doi.org/10.3390/vetsci8060095