Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Phellinus linteus on Differentiation and Cell Proliferation in Human Leukemia HL-60 cells

상황버섯이 인간 백혈병 세포주인 HL-60 세포의 분화유도 및 증식에 미치는 영향

  • Choi, Eun-Young (Graduate School of Education. Common-Science Education, Wonkwang University) ;
  • Ju, Seong-Min (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Jin-Mo (Division of Natural Science, College of Natural Sciences, Wonkwang University) ;
  • Park, Jun-Ho (Division of Natural Science, College of Natural Sciences, Wonkwang University) ;
  • Han, Dong-Min (Division of Natural Science, College of Natural Sciences, Wonkwang University) ;
  • Jeon, Byung-Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Won-Sin (Division of Natural Science, College of Natural Sciences, Wonkwang University)
  • 최은영 (원광대학교 교육대학원 공통과학교육) ;
  • 주성민 (원광대학교 한의과대학 병리학교실) ;
  • 박진모 (원광대학교 자연과학대학 생명과학부) ;
  • 박준호 (원광대학교 자연과학대학 생명과학부) ;
  • 한동민 (원광대학교 자연과학대학 생명과학부) ;
  • 전병훈 (원광대학교 한의과대학 병리학교실) ;
  • 김원신 (원광대학교 자연과학대학 생명과학부)
  • Published : 2007.10.25
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Abstract

We have examined the effect of water extract of Phellinus linteus, a raw material of Korean traditional herbal medicine, on the induction of HL-60 cell differentiation. The proliferation of HL-60 cell was inhibited dose-dependently by treatment with various doses of P. linteus extract. It also caused a significant change in NBT reduction (7.5 times). The expression of CD11b and CD14 was increased in the cells treated with the extract, especially in those arrested at G0/G1 stage, which suggested that some components in P. Linteus extract induced HL-60 cell differentiation to granulocytic and monocyte lineages. Moreover, the expression levels of $p21^{WAF1/CIP}$ and $p27^{KIP}$ were up-regulated during HL-60 cell differentiation induced by P. Linteus extract. These results together suggest that P. Linteus extract contains potential HL-60 cell differentiation agents.

Keywords

References

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