Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Acanthopanacis cortex Water Extract on Renal Function in Ischemia/Reperfusion-lnduced Acute Renal Failure Rats

오가피(五加皮) 물추출물이 허혈-재관류로 유발된 급성 신부전에 미치는 영향

  • Lee, An-Sook (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gil (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Eun-Ju (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Yang, Sun-Nye (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Uhm, Jae-Yeon (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • An, Jun-Seok (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 이안숙 (원광대학교 한의학전문대학원) ;
  • 강대길 (원광대학교 한의학전문대학원) ;
  • 김은주 (원광대학교 한의학전문대학원) ;
  • 양선녀 (원광대학교 한의학전문대학원) ;
  • 엄재연 (원광대학교 한의학전문대학원) ;
  • 안준석 (원광대학교 한의학전문대학원) ;
  • 이호섭 (원광대학교 한의학전문대학원)
  • Published : 2007.10.25
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Abstract

The present study was designed to examine whether water extract of Acanthopanacis cortex(AC) has an effect on renal functional parameters in association with the expression of aquaporin 2 (AQP-2) and heme oxygenase-1 (HO-1) in the ischemia/reperfusion induced acute renal failure (ARF) rats. Polyuria caused by down-regulation of renal AQP 2 in the ischemia-induced ARF rats was markedly restored by administration of AC (200 mg/kg, p.o.) with restoring expression of AQP 2 in the kidney. Administration of AC lowered the renal expression of HO-1, which was upregulated in rats with ischemia/reperfusion-induced ARF. The renal functional parameters including creatinine clearance, urinary sodium excretion, urinary osmolality, and solute-free reabsorption were also markedly restored in ischemia-ARF rats by administration of AC. Histological study also showed that renal damages in the ARF rats were abrogated by administration of AC. Taken together, the present data indicate that AC ameliorates renal defects in rats with ischemia/reperfusion-induced ARF.

Keywords

References

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