Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Buja${\cdot}$Padu${\cdot}$Daehwang${\cdot}$Seokgo Extract on UCPs Expression in Mice

부자${\cdot}$파두${\cdot}$대황${\cdot}$석고 추출물의 UCP 발현에 미치는 영향

  • Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Eun-Kyung (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, In-Seob (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Hwang, Tae-Ok (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Si-Woo (Korea Institute of Oriental Medicine) ;
  • Lee, Su-Kyung (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Choi, Jin-Young (Kunsan Oriental Hospital, Wonkwang University) ;
  • Keum, Kyung-Soo (Department of Classics, College of Oriental Medicine, Wonkwang University)
  • 권강범 (원광대학교 한의과대학 한방생리학교실) ;
  • 김은경 (원광대학교 한의과대학 한방생리학교실) ;
  • 김인섭 (원광대학교 한의과대학 한방생리학교실) ;
  • 황태옥 (원광대학교 한의과대학 한방생리학교실) ;
  • 이시우 (한의학연구원) ;
  • 이수경 (원광대학교 한의과대학 한방재활의학교실) ;
  • 최진영 (원광대학교 한의과대학 군산한방병원) ;
  • 금경수 (원광대학교 한의과대학 원전학교실)
  • Published : 2007.12.25
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Abstract

We designed to investigate the relationship the cold-hot theory of herbology and body temperature in experimental model. we prepared four kinds of oriental medicine, which consisted of two cold herbs, Daehwang and Seokgo, and two hot herbs, Buja and Padu. Decrease of body temperature by cold exposure for 12 hour was not inhibited by four herbs oral administration for two weeks. Thermogenesis in mammals is an essential physiological function to maintain the body temperature. Mitochondrial uncoupling proteins(UCPs), which have a potential to generate heat by uncoupling oxidative phosphorylation, apper to play a crucial role in thermogenesis. Therefore UCP is commonly recognized as a key molecule in metabolic thermogenesis and its dysfunction contributes to the development of obesity. In these experiments, Daehwang water extracts inhibited the UCP1 mRNA expression increase by cold exposure in brown adipose tissue. But other herbs did not significantly influence on UCPs mRNA expression in white adipose tissue and seleus muscle tissue. Based on this experiment, we will try to clarify the effects of Daehwang water extracts on UCP1 expression and function.

Keywords

References

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