Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Each Gastrodia elata Blume Concentration on Antidiabetic in Diabetic Mellitus Rats

당뇨유발 백서에서 천마의 농도별 투여가 항당뇨에 미치는 영향

  • Sim, Ki-Cheol (Department of Physical Therapy Dongshin University) ;
  • Kim, Eun-Jung (Department of Physical Therapy Dongshin University) ;
  • Pyo, Byoung-Sik (Department of Oriental Medicine & Material, Dongshin University) ;
  • Kim, Sun-Min (Department of Oriental Medicine & Material, Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy Dongshin University) ;
  • Chung, Hun-Woo (Department of Oriental Medicine, Dongshin University)
  • 심기철 (동신대학교 물리치료학과) ;
  • 김은정 (동신대학교 물리치료학과) ;
  • 표병식 (동신대학교 한약재산업학과) ;
  • 김선민 (동신대학교 한약재산업학과) ;
  • 김계엽 (동신대학교 물리치료학과) ;
  • 정현우 (동신대학교 한의학과)
  • Published : 2007.12.25
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Abstract

The antidiabetic effect of Gastrodia elata blume was investigated in streptozotocin-induced diabetic rats. Sprague-Dawley 30 rats, were divided into five groups, normal group(n=6), group Ⅰ was diabetic groups(n=6), group Ⅱ was diabetic induced and oral administration of Gastrodia elata blume extract 0.1 g/kg body weight(n=6) and group Ⅲ was diabetic induced and oral administration of Gastrodia elata blume extract 0.3 g/kg(n=6) and group Ⅳ was 0.5 g/kg(n=6) body weight for 28 days on Diabetic rats. Analysis the body weight, level of serum glucose, serum insulin, total cholesterol (TC), triglycerides (TG), aspartate transminase (AST), and alanine transaminase (ALT). Oral administrations of the Gastrodia elata blume extract significantly decreased weight, serum glucose, TC, TG, AST, and ALT levels, while increased in normal group. (p<0.05). TC and TG was significantly decreased in group Ⅲ and group Ⅳ. and AST, LT was no significantly in any groups. It is concluded that the Gastrodia elata blume must be considered as excellent candidate for future studies on diabetes mellitus.

Keywords

References

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