동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제21권6호
  • /
  • Pages.1520-1524
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  • 2007
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

LPS 유도 간독성에 대한 어성초 함유 혼합추출물의 항산화 효과

Effect of Houttuynia cordata Thunb and Herbs Mixture Extract on the Antioxidation in the LPS-induced Hepatotoxicity

  • 권륜희 (건양대학교 보건복지대학원 보건학과) ;
  • 나백주 (의과대학 예방의학교실) ;
  • 박시준 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이무식 (의과대학 예방의학교실) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Kwon, Ryun-Hee (Department of Public Health, Graduate School of Public Health and Welfare) ;
  • Na, Bak-Ju (Department of Preventive Medicine, College of Medicine, Konyang University) ;
  • Park, Si-Jun (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Moo-Sik (Department of Preventive Medicine, College of Medicine, Konyang University) ;
  • Mun, Yeun-Ja (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 발행 : 2007.12.25
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초록

The purpose of this study was to investigate the effects of Houttuynia cordata Thunb and Oriental Herb Mixture Extract (HCTM) through anti-oxidation against the hepatotoxicity-inducing lipopolysaccharide (LPS) in HCTM and LPS-treated rats. HCTM of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1.5 ml/kg for 20 days. On the day 21, 1.5 ml/kg of LPS was injected 5 hours before anesthetization. The activity of superoxide dismutase (SOD) was measured in mitochondrial fraction and malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx) were measured in liver homogenate. LPS-treatment markedly increased the levels of MDA and significantly decreased those of SOD, CAT and GPx. But HCTM pretreatment significantly increased those of SOD, CAT and GPx by 86.9%, 57.2% and 72.7% respectively. Moreover HCTM pretreatment decreased the levels of MDA. These results showed the HCTM had the effects against the hepatotoxicity-inducing LPS in the anti-oxidation. This suggested that HCTM could be used for functional beverage.

키워드

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