The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function

  • Kim, Jae-Goo (Departments of Pharmacology and Brain Korea 21 Project for Medical Sciences, Brain Research Institute, Yonsei University College of Medicine) ;
  • Kim, Min-Soo (Departments of Pharmacology and Brain Korea 21 Project for Medical Sciences, Brain Research Institute, Yonsei University College of Medicine) ;
  • Lee, Se-Oul (Department of Pharmacology, Wonkwang University College of Medicine) ;
  • Kim, Gun-Tae (Departments of Pharmacology and Brain Korea 21 Project for Medical Sciences, Brain Research Institute, Yonsei University College of Medicine) ;
  • Lee, Jong-Doo (Departments of Diagnostic Radiology and Brain Korea 21 Project for Medical Sciences, Brain Research Institute, Yonsei University College of Medicine2Diagnostic Radiology) ;
  • Kim, Dong-Goo (Departments of Pharmacology and Brain Korea 21 Project for Medical Sciences, Brain Research Institute, Yonsei University College of Medicine)
  • Published : 2007.06.30
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Abstract

Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a $5-HT_{1A}$ receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated groups. The LPS-treated group showed impaired motor coordination in the Rota-rod test. The LPS- treated or both LPS and NAN-190-treated groups showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is a promising strategy of establishing an animal model for developmental disabilities.

Keywords

References

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