Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Samul-Tang on the Allergic Inflammatory Response

사물탕(四物湯)이 알러지 염증반응에 미치는 영향

  • Kim, Eun-Kyoung (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Eun-Young (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Hyun-Sam (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Jung, Hyuk-Sang (Department of Anatomy, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Seong-Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University) ;
  • Sohn, Young-Joo (Department of Gynecology, College of Oriental Medicine, Sangji University) ;
  • Sohn, Nak-Won (Department of Anatomy, College of Oriental Medicine, Kyung Hee University)
  • 김은경 (경희대학교 한의과대학 해부학교실) ;
  • 김은영 (경희대학교 한의과대학 해부학교실) ;
  • 이현삼 (경희대학교 한의과대학 해부학교실) ;
  • 정혁상 (경희대학교 한의과대학 해부학교실) ;
  • 박성규 (경희대학교 한의과대학 처방제형학교실) ;
  • 손영주 (상지대학교 한의과대학교 부안과학교실) ;
  • 손낙원 (경희대학교 한의과대학 해부학교실)
  • Published : 2007.06.25
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Abstract

Samul-Tang (SMT) has been used for nourishing of the blood, hematopoiesis as a herbal medicine history. The purpose of this study is to find out anti-allergic inflammatory reaction of SMT. To clarify the mechanism, the effect of SMT on vascular permeability of rat cutaneous tissue and histamine and cytokines (IL-6, IL-8, TNF-${\alpha}$) release from mast cells were observed. The results are the pretreatment with SMT significantly decreased the compound 48/80-induced degranulation and histamine release from RPMC, SMT also inhibited the anti-DNP lgE-induced increment of vascular permeability of rat cutaneous tissue. SMT significantly reduced the PMA plus A23187-induced increment of expression of IL-6, IL-8, and TNF-${\alpha}$ in HMC-1 Cell. The Present study provide evidence that SMT inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression, and suggest the mechanisms of action. Furthermore, in vivo and in vitro anti-allergic effect of SMT suggests a possible therapeutic application of this agent in inflammatory allergic diseases.

Keywords

References

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