Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Chungyeoldodam-tang on Hypertension

청열도담탕이 고혈압에 미치는 영향

  • Park, Kyung-Ho (Department of Pathology, College of Oriental Medicine, Deajeon University) ;
  • Choi, Hak-Joo (Department of Pathology, College of Oriental Medicine, Deajeon University) ;
  • Roh, Seong-Soo (Laboratory of Herbology, College of Oriental Medicine, Deajeon University) ;
  • Koo, Young-Sun (Department of Internal Medicine, College of Oriental Medicine, Deajeon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Deajeon University)
  • 박경호 (대전대학교 한의과대학 병리학교실) ;
  • 최학주 (대전대학교 한의과대학 병리학교실) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 구영선 (대전대학교 한의과대학 내과학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2007.06.25
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Abstract

To access the safety and efficacy of Chungyeoldodam-tang(CDT), a traditional herbal medicine prescription, on hypertension we examined various parameters involved in the pathogenesis of hypertension. CDT seems to be safe because CDT at the concentrations lower that 250 ug/ml showed no toxic effects in cultured human fibroblast and no toxic effects on liver function. The production of reactive oxygen species (ROS) were greatly decreased in CDT treated group compared with control, and angiotensin converting enzyme activities were reduced by CDT in a dose dependent manner. There was no differences in weight of hearts between control and CDT treated group. The blood pressure and pulse rate were significantly decreased. CDT greatly reduced the levels of plasma hormones including aldosterone, dopamine, and norepinephrine, but not epinephrine, and serum electrocytes including Na$^+$ and Cl$^-$, but not K$^+$. were also decreased. The levels of uric acid, BUN and creatinine were significantly decreased compared with control. These results suggested that CDT has suppressive effects on various pathologic factors in hypertension, and CDT has potential as a safe and effective therapeutics for hypertension.

Keywords

References

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