Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Achyranthes Radix and Electroacupuncture on Type II Collagen-Induced Arthritis

류마티스 관절염에서 우슬과 전침자극의 항관절염 효과

  • Kim, Gye-Yeop (College of Health & Welfare of Dongshin University) ;
  • Seong, Rak-Seon (Team of Herbal Medicine Standardization, Korea Food and Drug Administration) ;
  • Kim, Young-Eok (College of Health & Welfare of Dongshin University) ;
  • Chang, Mee-Kyung (Department of Diet & Health Management Dongkang College) ;
  • Yu, Young-Dae (Department of Rehabilitation Medicine, Wonkwang University Medical Center) ;
  • Choi, Ki-Bok (College of Health & Welfare of Dongshin University) ;
  • Jeong, Hyun-Woo (Department of Oriental Medicine of Dongshin University)
  • 김계엽 (동신대학교 보건복지대학) ;
  • 성락선 (식품의약품안전청 생약규격팀) ;
  • 김용억 (동신대학교 보건복지대학) ;
  • 장미경 (동강대학 다이어트 건강관리과) ;
  • 유영대 (원광대학교 광주한방병원) ;
  • 최기복 (동신대학교 보건복지대학) ;
  • 정현우 (동신대학교 한의학과)
  • Published : 2007.04.25
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Abstract

The purpose of this study was to observe the effects of Achyranthes Radix(AR) and electroacupuncture(EA) in rats with rheumatoid arthritis induced by type II collagen for 28 days. Control group was daily administered 0.9% NaCl 0.5 $m{\ell}$, Group I was daily administered 0.9% NaCl 0.5 $m{\ell}$ to arthritic rats, Group II was orally administered with Achyranthes Radix 500 mg/kg 0.5 $m{\ell}$ to arthritic rats. Group III was given 2 Hz EA of chok samni acupoint(ST36) in the test group for 30 min/days to arthritic rats. Group IV was daily orally administered with Achyranthes Radix 500 mg/kg 0.5 $m{\ell}$ and 2 Hz EA of chok samni acupoint(ST36) in the test group for 30 min/days to arthritic rats. This studies have been designed to evaluate the hind paw edema, assessment of arthritis indices, analgetic effects by analysis of blood chemistry(WBC, CRP, ALP, AST). In each group, histologic observations, Safranin O-fast green stain were observed and analyzed. The following results were obtained. Group II, III, IV were significantly decreased arthritis indices and the rate of paw edema compared with Group I . Especially group IV was the most significantly decreased. The WBC, CRP, AST, ALT was that Group II, III, IV were significantly decreased compared with Group I . In conclusion, Achyranthes Radix and Ea contribute to the improvement of blood chemistry and change in safranin O-fast green by knee joint of arthritic rats.

Keywords

References

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