Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Therapeutic Efficacy of Extracts from Root of Acnthopanax Sessiliflorus as Anti-cancer Drug ; in vivo and in vitro Study

  • Kim, Hyung-Woo (Department of Herbology, College of Koran Medicine Dongshin University) ;
  • Jeong, Sun (Department of Herbology, College of Koran Medicine Dongshin University) ;
  • Baek, Gwang-Hyun (Department of Herbology, College of Koran Medicine Dongshin University) ;
  • Cho, Su-In (Department of Herbology, College of Koran Medicine Dongshin University) ;
  • Jeon, Byung-Gwan (Department of Environmental Engineering Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University) ;
  • Cho, Young-Lim (Department of Pathology, College of Korean Medicine Dongshin University) ;
  • Jeong, Hyun-Woo (Department of Pathology, College of Korean Medicine Dongshin University)
  • Published : 2007.04.25
Download PDF
⟨ Previous Next ⟩

Abstract

The cortex and root of Acnthopanax sessiliflorus, a herbal medicine, have been used for several diseases including cancer in Oriental countries. In the previous study, we showed that the cortex of this plant have anti-cancer activity. But its therapeutic efficacy of CORTEX ACANTHOPANAX RADICIS (CAR) is not clarified. For these reasons, we investigated immuno-potentiating and anti-cancer properties of CAR compared with CA, in terms of body and tumor weights, proliferation of thymocytes and tumor cells, and nitric oxide production from macrophages through in vitro and in vivo studies. In our results, administration of CAR reduced tumor mass and increased body weights. CAR also inhibited proliferation of tumor cells in vivo and in vitro dose-dependently. Thymocyte proliferation was accelerated by treatment with CAR and NO production was also promoted by CAR in vivo and vitro. In conclusion, we demonstrated that CAR is useful to treat for cancer as complementary or alternative medicine to Western medication, its therapeutic efficacy is involved in direct inhibition of tumor growth and immuno-potentiating activity.

Keywords

References

  1. Shin, M.K. Clinical Traditional Herbology, Young Lim Sa, Seoul, pp 717-718, 2000
  2. Jeong, S.C., Jeong, Y.T., Yang, B.K., Song, C.H. Chemical characteristics and immuno-stimulating properties of biopolymers extracted from Acanthopanax sessiliflorus, J Biochem Mol Biol. 39(1):84-90, 2006 https://doi.org/10.5483/BMBRep.2006.39.1.084
  3. Hahn, D.R., Kim, C.J. and Kim, J.H. A study on chemical constituents of Acanthopanax koreanum Nakai and its pharmaco-biological activities, Yakhak Hoeji 29: 357-361, 1985
  4. Yook, C.S., Rho, Y.S., Sed, S.H., Leem, J.Y. and Han, S.H. Chemical components of Acanthopanax divaricatus and anticancer effect in leaves, Yakhak Hoeji 40: 251-261, 1996
  5. Fujikawa, T., Yamaguchi, A., Morita, I., Takeda, H. and Nihshibe, S. Protective effects of Acantopanax senticosus Harms from Hokkai do and its components on gastric ulcer in restrained cold water stressed rats, Biol. Pharm. Bull. 19: 1227-1230, 1996 https://doi.org/10.1248/bpb.19.1227
  6. Yoshizumi, K., Hirano, K., Ando, H., Hirai, Y., Ida, Y., Tsuji, T., Tanaka, T., Satouchi, K., Terao, J. Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase, J Agric Food Chem 54(2):335-341, 2006 https://doi.org/10.1021/jf052047f
  7. Jin, J.L., Lee, S., Lee, Y.Y., Kim, J.M., Heo, J.E., Yun-Choi, H.S. Platelet anti-aggregating triterpenoids from the leaves of Acanthopanax senticosus and the fruits of A. sessiliflorus, Planta Med. 70(6):564-566, 2004 https://doi.org/10.1055/s-2004-827159
  8. Zhuravlev, IuN, Artiukova, E.V., Kozyrenko, M.M., Reunova, G.D. Genetic relationships among Far Eastern species of the family Araliacea inferred by RAPD analysis, Genetika 39(1):57-63, 2003
  9. Lee S., Ji, J., Shin, K.H., Kim, B.K. Sessiline, a new nitrogenous compound from the fruits of Acanthopanax sessiliflorus, Planta Med. 68(10):939-941, 2002 https://doi.org/10.1055/s-2002-34925
  10. Zhou, C.C. Anti-inflammatory action of ethanol extracts from Acanthopanax sessiliflorus, Chung Yao Tung Pao. 10: 37-41, 1985
  11. Fang, J.N., Proksch, A. and Wagner, H. Immunologically activity polysaccharides of Acanthopanax senticosus, Phytochemistry 24: 2619-2622, 1985 https://doi.org/10.1016/S0031-9422(00)80681-0
  12. Jeonf, H.W., Rho, Y.H., Lee, K.S., Kim, C.J., Jeon, B.G. The experimental effects of Acanthopanacis Cortex Extracts onthe Immunity, Anti-Cancer and Obesity in Animal, J. O. Physiology and pathology 19(2):389-397, 2005
  13. Wysocki, L.J. and Sato, V.L. 'Planning' for lymphocytes ; A method for cell selection, Proc. Nat1. Acad. Sci. 75(6):2844-2848, 1978
  14. Green, L.C., Wanger, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S. and Tannenbaum, S.R. Analysis of nitrite, and [15N] nitrate in biological fluids, Anal. Biochem. 126: 131-136, 1982 https://doi.org/10.1016/0003-2697(82)90118-X
  15. Gewirtz, D.A., Gupta, M.S., Sundaram, S. Vitamin D3 and vitamin D3 analogues as an adjunct to cancer chemo-therapy and radiotherapy, Curr Med Chem Anticancer Agents 2(6):683-690, 2002 https://doi.org/10.2174/1568011023353697
  16. Wen, M.C., Wei, C.H., Hu, Z.Q., Srivastava, K., Ko, J., Xi, S.T. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma, J Allergy Clin Immunol. 116: 517-524, 2005 https://doi.org/10.1016/j.jaci.2005.05.029
  17. Geenen, V., Martens, H., Brilot, F., Renard, C., Franchimont, D., Kecha, O. Thymic neuroendocrine self-antigens. Role in T-cell development and central T-cell self-tolerance, Ann N Y Acad Sci. 917: 710-723, 2000 https://doi.org/10.1111/j.1749-6632.2000.tb05435.x
  18. Hibbs, J.B., Taintor, R.R. and Vavrin, Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite, Science 235: 473-476, 1987 https://doi.org/10.1126/science.2432665