Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Mixture of Yukgunja-tang and Bambusae Caulis in Liquamen on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats

육군자탕(六君子湯)과 죽력(竹瀝) 혼합물이 국소 뇌혈류량 및 평균혈압에 미치는 효과

  • Lee, Seok-Jin (Department of Pathology, College of Oriental Medicine, Dongshin University) ;
  • Jeong, Hyun-Woo (Department of Pathology, College of Oriental Medicine, Dongshin University)
  • 이석진 (동신대학교 한의과대학 병리학교실) ;
  • 정현우 (동신대학교 한의과대학 병리학교실)
  • Published : 2007.02.25
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Abstract

The study was designed to investigate the effects of Mixture of Yukgunja-tang and Bambusae Caulis in Liquamen (YTBCL) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in rats, and further to determine the mechanism of action of YTBCL. The results in rats were as follows ; YTBCL 25 ${\mu}l$ significantly decreased rCBF and MABP compared with basal condition. YTBCL 100 ${\mu}l$ significantly increased rCBF compared with basal condition, but decreased MABP compared with basal condition. YTBCL 50 ${\mu}l$ significantly increased rCBF compared with basal condition, but MABP was somewhat decreased compared with basal condition. The VTBCL 50 ${\mu}l$-induced increase in rCBF was significantly inhibited by pretreatment with methylene blue (10 ${\mu}g$/kg, i.p.), an inhibitor of guanylate cyclase and indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase. The YTBCL 50 ${\mu}l$-induced decreased MABP significantly increased by pretreatment with methylene blue but was inhibited by indomethacin. This results were suggested that the mechanism of YTBCL was mediated Dy guanylate cyclase.

Keywords

References

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