Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Houttuyniae Herba Complex Prescription on Atopic Dermatitis in NC/Nga Mice

어성초복합방(魚腥草複合方)이 NC/Nga mouse 아토피 병태 모델의 관련 면역 세포 및 IgE 생성량에 미치는 영향

  • Hwang, Chang-Ha (Department of Pathology, College of Oriental Medicine, Daejeon University) ;
  • Jeong, Hye-Gwang (Department of Pharmacy, College of Phamacy, Research Center for Proteineous Materials, Chosun University) ;
  • Koo, Young-Sun (Department of internal Medicin, College of Oriental Medicine, Daejeon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University)
  • 황창하 (대전대학교 한의과대학 병리학교실) ;
  • 정혜광 (조선대학교 단백질소재연구센터) ;
  • 구영선 (대전대학교 한의과대학 내과학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2007.02.25
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Abstract

To examine the effects of HHCP on atopic dermatitis and its various immunopathologic parameters was induced by DNCB in NC/Nga mice and the animals were orally administrated with HHCP. We summarized the results obtained from serum levels of IgE and the numbers of various immune cells as follow. HHCP has no cytotoxic effects at the range of concentration (1-400 ${\mu}g$/ml) on fibroblast isolated from lung of BALB/c mice. HHCP significantly lowered the serum levels of IgE compared with control at 16 and 20 week. HHCP significantly reduced the number of CD19$^+$ cell in spleen and DLN, as well as the number of B220$^+$ /IgE$^+$ cell in DLN compared with control. HHCP significantly reduced the number of ${\alpha}$${\beta}$ TCR$^+$ in spleen and DLN, the number of CD8$^+$ in spleen compared with control, and also significantly reduced the number of CD3$^+$, CCR3, CD3$^+$/CD69$^+$, CD3/ CCR3, CD4$^+$, CD3$^+$/ CD4$^+$/CD45$^+$ cell in DLN. HHCP increased the number of NK$^+$ cells in spleen compared with control, in contrast significantly decreased the number of CD11c$^+$/ Classll$^+$ cell and CD11b$^+$/Gr-1$^+$ cell in DLN. Taken together, these results suggested that HHCP has suppressive effects on atopic dermatitis through the inhibition of IgE production and modulation of immune cell population in NC/Nga mice.

Keywords

References

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