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Antinociceptive and antidiarrhoeal activities of Bruguiera gymnorrhiza

  • Ahmed, F (Pharmacy Discipline, Khulna University) ;
  • Shahid, IZ (Pharmacy Discipline, Khulna University) ;
  • Gain, NC (Pharmacy Discipline, Khulna University) ;
  • Reza, MSH (Pharmacy Discipline, Khulna University) ;
  • Sadhu, SK (Pharmacy Discipline, Khulna University)
  • Published : 2007.09.30

Abstract

The methanol extract of leaves of Bruguiera gymnorrhiza (L.) Lam. (Rhizophoraceae) was screened for its antinociceptive and antidiarrhoeal activities. The extract produced significant inhibition in acetic acid-induced writhing in mice at dose of 250 and 500 mg/kg body weight (P < 0.001), comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight (P < 0.001). When tested for its antidiarrhoeal effects on castor oil-induced diarrhea in mice, it increased mean latent period (P < 0.02) and decreased the frequency of defecation (P < 0.01) significantly at the dose of 500 mg/kg body weight, comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. The overall results tend to suggest the antinociceptive and antidiarrhoeal activities of the extract.

Keywords

References

  1. Achmadi S, Syahbirin G, Choong ET, Hemingway RW. (1994) Catechin-3-O-rhamnoside chain extender units in polymeric procyanidins from mangrove bark. Phytochemistry 35, 217-219 https://doi.org/10.1016/S0031-9422(00)90537-5
  2. Ahmed F, Selim MST, Das AK, Choudhuri MSK. (2004) Anti-inflammatory and antinociceptive activities of Lippia nodiflora Linn. Pharmazie 59, 329-330
  3. Balasooriya SJ, Sotheeswaran S, Balasubramanium S. (1982) Economically useful plants of Srilanka, Part IV. Screening for Sri Lanka plants for tannins. J. Nat. Sci. Counc. 10, 213-219
  4. Beubler E, Juan H. (1979) Effect of Ricinoleic acid and other Laxatives in Net Water Flux and Prostaglandin E release by the Rat Colon. J. Pharm. Pharmacol. 31, 681-685
  5. Chatterjee TK. (1993) Handbook of laboratory Mice and Rats. 1st edition, pp. 133-139. Jadavpur University, India
  6. Derardt R, Jougney S, Delevalcee F, Falhout M. (1980) Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur. J. Pharmacol. 51, 17-24 https://doi.org/10.1016/0014-2999(80)90377-5
  7. Evans WC. (1989) Trease and Evan's Textbook of Pharmacognosy. 13th edition, p. 546. Cambridge University Press, London
  8. Ghani A. (1998) Medicinal Plants of Bangladesh. The Asiatic Society of Bangladesh, Dhaka, Bangladesh, 1st edition
  9. Ghosh A, Misra S, Dutta AK, Choudhury A. (1985) Pentacyclic triterpenoids and sterols from seven species of mangrove. Phytochemistry 24, 1725-1727 https://doi.org/10.1016/S0031-9422(00)82541-8
  10. Han L, Huang X, Sattler I, Dahse HM, Fu H, Grabley S, Lin W. (2005) Three new pimaren diterpenoids from marine mangrove plant, Bruguiera gymnorrhiza. Pharmazie 60, 705-707
  11. Hogg RW, Gillan FT. (1984) Fatty acids, sterols and hydrocarbons in the leaves from eleven species of Mangrove. Phytochemistry 23, 93-97 https://doi.org/10.1016/0031-9422(84)83084-8
  12. Homhual S, Zhang HJ, Bunyapraphatsara N, Kondratyuk TP, Smtarsiero BD, Mesecar AD, Herunsalee A, Chaukul W, Pezzuto JM, Fong HH. (2006) Bruguiesulfurol, a new sulfur compound from Bruguiera gymnorrhiza. Planta Med. 72, 255-260 https://doi.org/10.1055/s-2005-873171
  13. Rollet B. (1981) Bibliography of Mangrove research. 1600-1975. UNESCO Paris. p.479. Pub. Information Retrieval Ltd., London
  14. Racusen LC, Binder HJ. (1979) Ricinoleic acid stimulation of active anion secretion in colonic mucosa of the rat. J. Clin. Invest. 63, 743-749
  15. Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, Scheffer JJC. (2003) Anti-inflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir. J. Ethnopharmacol. 84, 31-33 https://doi.org/10.1016/S0378-8741(02)00264-7
  16. Whittle BA. (1964) The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics. Br. J. Pharmacol. Chemother. 22, 246-253