Advances in Traditional Medicine

  • 제7권3호
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  • Pages.304-310
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  • 2007
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Monocrotophos induced inhibition of the activities of testis and accessory reproductive organs in male mice

  • Patill, Saraswati B (Reproductive Biology Research Unit. Department of Post-graduate Studies and Research in Zoology, Gulbarga University) ;
  • Malashetty, Vijaykumar B (Reproductive Biology Research Unit. Department of Post-graduate Studies and Research in Zoology, Gulbarga University)
  • 발행 : 2007.09.30
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초록

Monocrotophos was administered orally to adult male albino mice at dose level of 3.0 mg/kg body weight/day/mice for 50 days. The treatment has found to affect spermatogenesis as well as the endocrine functions of the testis as indicated by gravimetric, histopathological and biochemical changes. The treatment has caused degenerative changes in the seminiferous tubules and Leydig cells of the testis and regression of the epididymis, seminal vesicle, vas deferens, prostate, Cowper's gland and levator ani. Similarly, cauda epididymal sperm count and sperm motility have shown significant reduction. There was a significant reduction in the protein, glycogen, sialic acid, acid and alkaline phosphatase and increase in cholesterol in the testis of monocrotophos treated mice compared with the control. The causative factors for these changes due to monocrotophos administration were discussed.

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참고문헌

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