Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Growth Inhibitory Effect of Irradiated Green Tea Polyphenol Addition in Cosmetic Composition

녹차 폴리페놀을 첨가한 화장품의 암 세포증식억제 효과

  • Park, Tae-Soon (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Lee, Jin-Young (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Park, Gun-Hye (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Hyun, Sok-Jun (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Lee, Jin-Tae (Department of Cosmeceutical Science, Daegu Haany University) ;
  • Cho, Young-Je (Department of Food Engineering, Sangju National University) ;
  • Kim, Young-Sun (LeeJiHam Cosmetics Ltd.) ;
  • An, Bong-Jeun (Department of Cosmeceutical Science, Daegu Haany University)
  • 박태순 (대구한의대학교 화장품약리학과) ;
  • 이진영 (대구한의대학교 화장품약리학과) ;
  • 박근혜 (대구한의대학교 화장품약리학과) ;
  • 현석준 (대구한의대학교 화장품약리학과) ;
  • 이진태 (대구한의대학교 화장품약리학과) ;
  • 조영제 (상주대학교 식품공학과) ;
  • 김영선 ((주)이지함 화장품) ;
  • 안봉전 (대구한의대학교 화장품약리학과)
  • Published : 2007.09.30
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Abstract

Cosmetic products including toner and essence were manufactured to evaluate the effect of green tea polyphenols. In addition, irradiation was applied to remove an undesirable color of green tea polyphenol(GTP), which may cause a problem in marketing. The growth inhibition rates of GTP, PT, and PE on all cell lines were shown to be over 80% at 500 ppm concentration. Especially the growth inhibition rates of GTP, PT, and PE on human melanoma(G361) cells were shown to be over 80% at only 100 ppm concentration. Results indicate that the addition of irradiated green tea polyphenol may be effective in the manufacturing of functional cosmetics including toner and essence with various anti-cancer activities.

화장품에 폴리페놀을 다량 첨가 시 색소가 문제시 될 수 있어 이를 제거하기 위하여 폴리페놀을 첨가한 토너와 에센스에 방사선을 5, 10, 20 kGy로 조사하고, 조사량에 따른 암세포증식 억제능을 검토하였다. 암세포 증식 억제능 측정 결과 모든 세포주(B16F10, G361, A549, HT-29)에 대하여 폴리페놀이 첨가된 토너와 에센스는 500 ppm에서 80% 이상의 증식 억제능을 나타내었으며, 특히 human melanoma(G361)에서는 100 ppm에서 80% 이상의 뛰어난 암세포 증식 억제 효과를 나타내었으며, 방사선 조사량이 증가해도 폴리페놀의 활성이 유지되었다. 또한, 방사선 조사량이 증가 할수록 색이 점차적으로 옅어짐을 확인할 수 있었다. 이와 같은 결과로 미루어 보아 녹차 폴리페놀을 토너와 에센스에 첨가했을 때 암세포증식 억제능이 우수하였으며, 화장품에 첨가 시 나타나는 색소문제는 방사선 조사를 이용하여 개선이 될 것으로 사료된다.

Keywords

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