Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of BHOSB on Various Immunological Factors Related to Pathogenesis of Atopic Dermatitis in DNCB Treated NC/Nga Mice

비허온습만(脾虛蘊濕万)이 아토피 피부염 유발 NC/Nga 생쥐의 혈액내 면역 관련 인자에 미치는 영향

  • Park, Sung-Hee (Department of Pathology, College of Oriental medicine, Daejon University) ;
  • Jin, Mi-Rim (Department of Pathology, College of Oriental medicine, Daejon University) ;
  • Koo, Young-Sun (Department of Internal Medicine, College of Oriental medicine, Daejon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Oriental medicine, Daejon University)
  • 박성희 (대전대학교 한의과대학 병리학교실) ;
  • 진미림 (대전대학교 한의과대학 병리학교실) ;
  • 구영선 (대전대학교 한의과대학 내과학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Published : 2007.08.25
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Abstract

Atopic dermatitis is an allergic inflammatory skin disease caused by aberrant and overreactive immune responses including overactivation of $T_H2$ immune responses, high levels of IgE as well as proinflammatory cytokines and chemokines. We examined whether BHOSB, a traditional herbal medicine, has modulatory effects on various immunological factors related to pathogenesis of atopic dermatitis in ONCB treated NC/Nga mice. Oral administration of BHOSB at the concentration of 10.8 mg/mouse/day significantly inhibited the production of IgE compared with control, and the levels of IgG2a and IgG2b, but not IgG1, were also significantly reduced. Production of IL-6 and TNF-a was greatly decreased. The results from flowcytometry of peripheral blood mononuclear cells indicated that the percentages of C03+C069+ cells and C04+ were significantly decreased by BHOSB. Theses results suggested that BHOSB has suppressive effects on aberrant and overreactive immunological activities in ONCB-induced dermatitis mice of NC/Nga.

Keywords

References

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