Advances in Traditional Medicine

  • 제8권4호
  • /
  • Pages.354-364
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  • 2008
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Effect of an herbal formulation on DOCA-salt and fructose induced models of hypertension in rats

  • Athare, CL (Department of Pharmacology, M. G. V's Pharmacy College) ;
  • Mohan, M (Department of Pharmacology, M. G. V's Pharmacy College) ;
  • Kasture, SB (Department of Pharmacology, M. G. V's Pharmacy College)
  • 발행 : 2008.12.31
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초록

The present study was carried out to investigate the antihypertensive effect of a folklore herbal formulation (HF) (300mg/kg/day; p.o.) in deoxycorticosterone acetate (DOCA)-salt induced and fructose induced hypertensive rats. In DOCA model, DOCA (15 mg/kg, s.c., twice a week) was administered to unilateral nephrectomized rats for 4 weeks. In fructose model, drinking water was replaced with 10% fructose solution for 6 weeks to induce hypertension. Systolic blood pressure (BP) was measured once every week during the treatment schedule. After completion of treatment schedule, BP and vascular reactivity to various agonists like Noradrenaline, Adrenaline, Phenylephrine and Serotonin (5-hydroxytrptamine; 5-HT) were recorded in rats of both models. A cumulative concentration response curve of 5-HT was carried out in isolated rat fundus strip of the DOCA-salt induced and fructose induced hypertensive rats. The results tend to suggest that HF possesses antihypertensive activity.

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