Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Anti-inflammatory and Antimicrobial activities of Petroleum ether and Ethanol extracts of Scutia myrtina (Rhamnaceae)

  • Kritheka, N (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Kumar, R Sambath (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Kumar, S Suresh (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Murthy, N Venkateswara (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Sundram, R Shanmuga (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Perumal, P (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy)
  • Published : 2008.12.31
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Abstract

The aim of the present study is to investigate the anti-inflammatory and antimicrobial activity of petroleum ether and ethanol extracts of Scutia myrtina (Family: Rhamnaceae). In anti-inflammatory activity carrageenan and histamine induced paw oedema and cotton pellet induced granuloma for acute and chronic inflammatory models were studied in Wister albino rats. Based on the results of the present study it can be concluded that petroleum ether and ethanol extract of Scutia myrtina at 400 mg/kg has potential anti-inflammatory effect and they act in a dose dependent manner. Both extracts of Scutia myrtina showed antimicrobial activity against all bacterial and fungal strains tested at the concentration of $100\;{\mu}g$/ml. From the result, it can be concluded that the Scutia myrtina contain antibacterial and antifungal principle. Further more, besides the confirmation of the popular use; the obtained results demonstrate this herbal drug to represent a new source of antimicrobial and anti-inflammatory agent.

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References

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