DOI QR코드

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Anti-inflammatory and Antimicrobial activities of Petroleum ether and Ethanol extracts of Scutia myrtina (Rhamnaceae)

  • Kritheka, N (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Kumar, R Sambath (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Kumar, S Suresh (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Murthy, N Venkateswara (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Sundram, R Shanmuga (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy) ;
  • Perumal, P (Department of Pharmaceutics and Pharmaceutical Chemistry, Natural Product Research Laboratory, J.K.K. Nataraja College of Pharmacy)
  • 발행 : 2008.12.31

초록

The aim of the present study is to investigate the anti-inflammatory and antimicrobial activity of petroleum ether and ethanol extracts of Scutia myrtina (Family: Rhamnaceae). In anti-inflammatory activity carrageenan and histamine induced paw oedema and cotton pellet induced granuloma for acute and chronic inflammatory models were studied in Wister albino rats. Based on the results of the present study it can be concluded that petroleum ether and ethanol extract of Scutia myrtina at 400 mg/kg has potential anti-inflammatory effect and they act in a dose dependent manner. Both extracts of Scutia myrtina showed antimicrobial activity against all bacterial and fungal strains tested at the concentration of $100\;{\mu}g$/ml. From the result, it can be concluded that the Scutia myrtina contain antibacterial and antifungal principle. Further more, besides the confirmation of the popular use; the obtained results demonstrate this herbal drug to represent a new source of antimicrobial and anti-inflammatory agent.

키워드

참고문헌

  1. Chhabra SC, Mahunnah RLA, Mshiu EN. (1991) Plants used in Traditional Medicine in Eastern Tanzania. V. Angiosperms (Passifloraceae to Sapindaceae). J. Ethnopharmacol. 7, 143-157 https://doi.org/10.1016/0378-8741(91)90173-B
  2. Cuman, RKN, Bersani-Amadio CA, Fortes ZB. (2001) Influence of type 2 diabetes on the inflammatory response in rats. Inflam. Res. 50, 460-465 https://doi.org/10.1007/PL00000271
  3. Dunne MW. Pathophysiology: Concepta of altered Health States with Contributors, In: Porth CM, Lippincott eds. Philadlphia, pp. 165-176
  4. Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. (1968) Screening of Indian plants for biological activity Indian J. Exp. Biol. 6, 232-247
  5. Hedberg I, Hedberg O, Mashigeni KE, Mshiu, EN, Samuelsson G, (1983) Inventory of plants usedin traditional medicine in Tanzania, part III Plants the families Papilionaceae-Vitaceae. J. Ethnopharmacol. 9, 237-260 https://doi.org/10.1016/0378-8741(83)90034-X
  6. El-shenawy SM, Abdel-salam OM, Baiuomy AR, El-batran S, Arbid MS (2002) Studies on the antiinflammatory and anti-nociceptive effects of melatonin in the rat. J. Pharmacol. 46, 235-243
  7. Gakunju DMN, Mberu EK, Dossaji SF, Gray AI, Waigh RD, Waterman PG, Watkins WM. (1995) Potent antimalarial activity of the Alkaloid Nitidine, Isolated from a Kenyan herbal remedy. Antimicrob. Agent's Chimother. 39, 2606-2609
  8. Kaij-A-Kamb M, Amoros M, Girre L. (1992) Search for new antiviral agents of plant origin. Pharma. Acta. Helv. 67, 130-147
  9. Kokwaro JO. (1976) Medicinal plants of East Africa. East Africa literature bureau, Nairobi
  10. Litchfield JT, Wilcoxon F. (1949) A simplified method of evaluating dose effect experiments. J. Pharmacol. Exp. Ther. 96, 99-133
  11. Ogonowski AA, May WS, Moor AB, Barret LT, Bryant CL, Pollock SH. (1997) Anti-inflammatory and analgesic activity of an inhibitor of neuropeptide amidation. J. Pharm. Exp. Ther. 280, 846-853
  12. Plummer JL, Cmielewski PL, Gourly GK, Owen H, Cousins M. (1996) Assessment of antinociceptive drug effects in the presence of impaired motor performance. J. Pharmacol. Meth. 26, 79-84 https://doi.org/10.1016/0160-5402(91)90057-C
  13. Suleyman H, Buyukokuroglu ME. (2001) The effects of newly synthesized pyrazole derivatives on formaldehyde, carragennan and dextran-induced acute paw oedema in rats. Biol. Pharm. Bull. 24, 1133-1136 https://doi.org/10.1248/bpb.24.1133
  14. Suleyman H, Demirezer LO, Kuruuzum A, Banoglu ZN, Gocer F, Ozbakir G, Gepdireman A. (1991) Anti-inflammatory effect of the aqueous extract from Rumex patientia L. roots, J. Ethnopharmacol. 65, 141-148 https://doi.org/10.1016/S0378-8741(98)00175-5
  15. Recio MC, Giner GM, Manez S, Ros JL. (1995) Structural requirements for the anti-inflammatory activity of natural terpenoids. Planta. Med. 6, 182-185 https://doi.org/10.1055/s-2006-958045
  16. Winter CA, Poster CC. (1957) Effect of alteration in side chain up on anti-inflammatory and liver glycogen activities in hydrocortisone ester. J. Am. Pharmacol. Soc. 46, 515-519
  17. Winter CA, Risely EA, Nuss GW. (1962) Carrageenan induced oedema in hind paw of the rat as assays for anti-inflammatory drugs. Exp. Biol. Med. 111, 544-547