Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Evaluation of anti-inflammatory activity of Solanum trilobatum roots

  • Pandurangan, A (Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology) ;
  • Khosa, RL (Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology) ;
  • Hemalatha, S (Department of Pharmaceutics, Banaras Hindu University)
  • Published : 2008.12.31
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Abstract

This study evaluated the anti-inflammatory potential of the crude alkaloidal fraction (CAF) of methanol extract of Solanum trilobatum Linn. (Solanacea) root in animal models of inflammation. Crude alkaloidal fraction at doses of 25, 50 and 100 mg/kg significantly (p < 0.01) reduced carrageenan induced rat paw volume at 3 h after carrageenan challenge as compared to control group of animals. CAF (25, 50 and 100 mg/kg) significantly (p < 0.01) and dose dependently suppressed cotton pellet induced granuloma formation. Topical application of CAF (1, 5 and 10 mg/ear) markedly inhibited multiple application of TPA in mice. CAF elicited pronounced inhibitory effects on formaldehyde and adjuvant induced arthritis in rats. These results indicate that CAF of methanol extract of the Solanum trilobatum has anti-inflammatory activity in acute and chronic inflammation.

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