Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of the Ethanol Extract from Lavandula vera on ${\alpha}$-MSH Induced Melanogenesis

라벤더 에탄올 추출물이 ${\alpha}$-MSH 유도 멜라닌 생성에 미치는 효과

  • Kim, Ho-Min (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Jang, Yeong-Mi (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Han, Kyu-Soo (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Moon, Dea-Won (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Mun, Yeun-Ja (Department of Anatomy, College of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Research Center of Traditional Korean Medicine, Wonkwang University)
  • 김호민 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 장영미 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 한규수 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문대원 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문연자 (원광대학교 한의과대학 해부학교실) ;
  • 우원홍 (원광대학교 한국전통의학연구소)
  • Published : 2008.12.25
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Abstract

Down-regulation of melanin synthesis is required for recovery of pigmentary disorders and it is well known that ${\alpha}$-MSH induced melanin synthesis and dendrite outgrowth on melanocytes. This study was conducted to evaluate the depigmenting properties of ethanol extract from a Lavandula vera. The ethanol extract from Lavandula vera inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the ethanol extract of Lavandula vera effectively suppressed the ${\alpha}$-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the ${\alpha}$-MSH-induced mRNA expression of tyrosinase was significantly attenuated by Lavandula vera treatment. These results suggest that Lavandula vera exerts its depigmenting effects through the suppression of tyrosinase and cytoplasmic dendricity. And it may be a potent depigmetation agent in hyperpigmentation condition.

본 논문은 라벤더 에탄올 추출물이 ${\alpha}$-MSH 유도 멜라닌 생성에 미치는 효과에 관한 것으로 라벤더 추출물이 미백효과에 미치는 연구를 중심으로 한다. 라벤더 에탄올 추출물은 복용 의존적으로 멜라닌 함량과 티로시나아제 활성을 억제했다. 라벤더 에탄올 추출물 처치는 ${\alpha}$-MSH로 촉진된 멜라닌 형성, 티로시나아제 활성, 수상돌기 성장을 효과적으로 억제했고, 라벤더 처치에 의해${\alpha}$-MSH로 유도된 티로시나아제의 mRNA 발현이 유의미하게 감소되었다. 본 연구를 통해 라벤더 추출물이 미백효과가 있음을 알 수 있었으며, 따라서 라벤더가 색소과다침착증에 미백제로 사용될 가능성이 있다는 내용이다.

Keywords

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