Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Clinical Research of Atopic Dermatitis Treated by Hwangryeonhaedok-Tang in Cosmetics

아토피 피부염 환자에서 황연해독탕(黃連解毒湯)이 함유된 한방화장품에 대한 임상 연구

  • Yun, Dae-Chul (Department of Ophthalmology & Otolaryngology & Dermatology, Semyung University) ;
  • Kim, Hee-Taek (Department of Ophthalmology & Otolaryngology & Dermatology, Semyung University) ;
  • Kim, Ee-Hwa (Department of Acupoint & Meridian, College of Oriental Medicine, Semyung University) ;
  • Ho, Dong-Su (The Clinical Trial Center for Bio-Industry at Semyung University)
  • 윤대철 (세명대학교 한의과대학 안이비인후피부과교실) ;
  • 김희택 (세명대학교 한의과대학 안이비인후피부과교실) ;
  • 김이화 (세명대학교 한의과대학 경혈학교실) ;
  • 호동수 (세명대학교 한방바이오산업 임상지원센터)
  • Published : 2008.12.25
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Abstract

This clinical research was conducted to test patients with Atopic Dermatitis by external application with Hwangryeonhaedok-Tang in cosmetics. We gave scores to 31 patients who visited the Dept. of Oriental Medical Opthalmology & Otolaryngology & Dermatology of Semyung University Jecheon Oriental Medical Hospital from May 15th, 2008 to June 26th. Fifteen patients were treated with the ointment that contain Hwangryeonhaedok-Tang (experimental group) and sixteen patients were treated with normal ointment that doesn't have Hwangryeonhaedok-Tang (control group) for 4 weeks. We observed change of total IgE, eosinophil count, Skin Temperature, Transepidermal Water Loss(TEWL), Skin Hydration and Skin pH. Also Clinical Index of Atopic Dermatitis(SCORAD Index) and global assesment of efficacy were used to evaluate the effects of Hwangryeonhaedok-Tang. Statistical analysis was performed by using frequency analysis and descriptive analysis. Statistical significance was achieved if the probability was less than 5%(p<0.05). After 4 weeks of external application treatment, SCORAD Index in experimental group was significant statistically decreased compared with control group. After 4 weeks of external application treatment, total IgE of both groups were decreased and eosinophil count in control group was decreased but experimental group was unstatistically decreased. Unstatistically, both groups didn't showed significant effect on Skin Temperature. Transepidermal Water Loss(TEWL) in both groups were increased but experimental group was significant decreased compared with control group. Skin Hydration in experimental group was significant statistically increased compared with control group. Statistically, both groups didn't showed significant effect on Skin pH. Only experimental group showed little increase. After 4 weeks of external application treatment, experimental group showed significant effect on global assesment of efficacy. Considering the above results, we can speculate that cosmetics with Hwangryeonhaedok-Tang has some therapeutical effects in mitigating the symptoms of Atopic Dermatitis.

Keywords

References

  1. Shultz, L.F., Hanifin, J.M. Epidemiology of atopic dermatitis. Immunol Allergy Clin North AM. 22: 1-24, 2002. https://doi.org/10.1016/S0889-8561(03)00066-3
  2. Oh, J.W., Kim, K.E., Pyun, B.Y. Nationwide study for epidemiological changes of atopic dermatitis in school aged children between 1995 and 2000 and kindergarten aged children in 2003 in Korea. Pediatr Allergy Resir Dis. 13(4):227-237, 2003.
  3. Bos, J.D., Wierenga, E.A., Sillevis, J.H., Heijden, F.L., Kapsenberg, M.L. Immuune dysregulation in atopic eczema. Arch Dermatol. 128: 1509-1512, 1992. https://doi.org/10.1001/archderm.128.11.1509
  4. Taieb, A. Hypothesis: from epidermal barrier dysfunction to atopic disorders. Contact Dermatitis. 41: 177-180, 1999. https://doi.org/10.1111/j.1600-0536.1999.tb06125.x
  5. 안석용, 안성구, 이승헌. 아토피 피부염과 피부장벽. 한국피부장벽학회지 8(1):47-51, 2006.
  6. Ogawa, H., Yoshiike, T. A speculative view of atopic dermatitis: barrier dysfunction in pathogenesis. J Dermatol Sci. 5: 197-204, 1993. https://doi.org/10.1016/0923-1811(93)90767-J
  7. 윤상웅, 황인아, 유종엽, 박경찬. 녹차추출물을 함유한 보습제의 항염증 효과 평가. 대한피부과학회지 41(1):15-20, 2003.
  8. Bohme, M., Svenson, A., Kull, I., Nordvall, S.L., Wahlgren, C.F. Clinical features of atopic dermatitis at two years of age. A prospective, population-based case-control study. Acta Derm Venerol. 81: 193-197, 2001. https://doi.org/10.1080/000155501750376294
  9. 박영립, 김형동, 김규한, 김명남, 김진우, 노영석, 받천욱, 이광훈, 이애영, 조상현, 최지호. 아토피피부염 학회 보고서: 한국인 아토피피부염의 진단기준에 대한 연구. 대한피부과학회지 44(6):659-663, 2006.
  10. Kim, K.H., Hwang, J.H., Park, K.C. Periauricular eczematization in chilldhood atopic dermatitis. Ped Dermatol. 14: 278-280, 1996.
  11. Kanwar, A.J., Dhar, S., Kaur, S. Evaluation of minor clinical features of atopic dermatitis. Ped Dermatol. 8: 114-116, 1991. https://doi.org/10.1111/j.1525-1470.1991.tb00297.x
  12. Sevensson, A., Edman, B., Moller, H. A diagnostic tool for atopic dermatitis based on clinical criteria. Acta Derm Venereol (Stockh) Suppl. 114: 33-40, 1985.
  13. Moller, H. Clinical aspects of atopic dermatitis in children. Acta Derm Venereol (Stockh) Suppl. 95: 25-28, 1981.
  14. 대한피부과학회 교과서 편찬위원회. 피부과학 제5판. 여문각, 서울, pp 170-178, 2008.
  15. Eigenmann, P.A. Clinical features and diagnostic criteria of atopic dermatitis in relation to age. Pediatr Allergy Immunol. 12: 69-74, 2001. https://doi.org/10.1034/j.1399-3038.2001.121416.x
  16. Park, Y.M., Park, H.J., Kim, T.Y., Kim, J.W. The study on the hospital-based relative frequency, and clinical and laboratory findings of atopic dermatitis. Korean J Dermatol. 35: 96-106, 1997.
  17. 이지현, 김규한, 김명남, 김진우, 노영석, 박영립, 박천욱, 이광훈, 이애영, 조상현, 최지호. 아토피피부염학회 보고서: 한국 아토피피부염의 치료지침 대한피부과학회지 44(8):907 -913, 2006.
  18. 박영립. 아토피피부염에서 보습제 사용. 한국피부장벽학회지 19(1):37-40, 2007.
  19. 최인화, 채병윤. 아토피 피부염에 관한 임상적 연구. 대한한의사협회지 12(1):73-83, 1991.
  20. Hill, C.J., Rosenberg, A. Jr. Adverse effects from topical steroids. Cutis. 21: 624-628, 1978.
  21. Ruiz-Maldonado, R., Zapata, G., Lourdes, T., Robles, C. Cushing's syndrome after topical application of corticosteroids. Am J Dis Child. 136: 274-275, 1982.
  22. McLean, C.J., Lobo, R.F., Brazier, D.J. Cataracts glaucoma, and femoral avascular necrosis caused by topical corticosteroids ointment. Lancet. 345: 330, 1995.
  23. Bode, H.H. Dwarfism following long-term topical corticosteroid therapy. JAMA. 244: 813-814, 1980. https://doi.org/10.1001/jama.244.8.813
  24. Queille, C., Pommarede, R., Saurat, J.H. Efficacy versus systemic effect of six topical steroids in the treatment of atopic dermatitis of childhood. Pediatr Dermatol. 1: 246-253, 1984. https://doi.org/10.1111/j.1525-1470.1984.tb01124.x
  25. 이희정, 박창욱, 이주희, 이광훈. 상인 아토피피부염 환자에서 삶의 질 평가의 임상적 유용성. 대한피부과학회지 45(2):159-164, 2007.
  26. 신나라, 김성현, 조소연, 황규광, 함정희. 소아기 아토피 피부염이 가족에 미치는 영향에 관한 연구. 대한피부과학회지 38(4):494-499, 2000.
  27. 양수진, 윤숙정, 이재욱, 이지범, 김성진, 원영호, 이승철. 소아에서 아토피 피부염의 중증도와 정신, 행동 및 가족 문제의 관련성. 대한피부과학회지 43(9):1170-1176, 2005.
  28. 공남미, 지선영. 아토피 피부염의 양 한방적 고찰. 대한외관과학회지 12: 241-253, 1999.
  29. 朴志修, 金允姬. 아토피 환자의 식이요법 및 외용요법의 조사와 체질별 적용. 대한한방소아과학회지 17(2):85-101, 2003.
  30. 장은영, 정승원, 안강모, 이상일. 소아 아토피 피부염에서의 대체보완요법 이용에 관한 연구. 천식 및 알레르기 학회지25(2):110-116, 2005.
  31. 김창훈, 김정태, 정현아, 노석선. 아토피 피부염 환자에서 한방 추출물이 포함된 외용 제품에 대한 임상효과. 한방안이비인후피부과학회지 20(2):187-198, 2007.
  32. 황순이, 황보민, 지선영, 김소연, 권영규, 서정철. 아토피 피부염 환자에서 七葉膽을 함유한 화장품의 임상적 연구. 한방안이비인후피부과학회지 20(3):212-221, 2007.
  33. 葛仙翁. 肘後備急方. 集文書局, 臺北, 3-8-9, 1978.
  34. 王燾. 外臺秘要. 國立中國醫藥硏究所, 臺北, p 72, 1968.
  35. 이인수, 김희택, 이은용, 김이화, 류주현. 黃連解毒湯의 사람 비점막 섬유아세포 IL-8 분비에 대한 효과. 대한안이비인후피부과학회지16(3):68-81, 2003.
  36. 최유성, 유충의, 박미연, 손숙자, 황규왕. 아토피 피부염의 중증도에 따른 임상 및 검사실 소견에 관한연구. 대한피부과학회지 44(7):824-829, 2006.
  37. 김명남, 신봉주, 탁우정, 노병인, 박애자. 아토피 피부염에서 말초 혈액내 호산구 수, 혈청IgE, eosinophil cationic proteinm, IL-4 및 soluble E-selection의 변화. 대한피부과학회지 40(11):1367-1373, 2002.
  38. Kim, D.W., Park, J.Y., Na, G.Y., Lee, S.J., Lee, W.J. Correlation of clinical features and skin barrier function in adolescent and adult patients with atopic dermatitis. Int J Dermatol. 45(6):698-701, 2006. https://doi.org/10.1111/j.1365-4632.2005.02644.x
  39. 장윤환, 김효진, 성현철, 김도원, 이원주, 나건연. Tape Stripping에 의한 각질층 제거 정도에 따른 피부장벽기능의 변화. 대한피부과학회지 43(7):919-925, 2005.
  40. 소병화. 피부효과의 기기평가. 한국 피부장벽학회지 8(1):68- 75, 2006.