DOI QR코드

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Antimicrobial activity and toxicity of Quisqualis indica

  • Jahan, Fatima N. (Department of Pharmacy, The University of Asia Pacific) ;
  • Rahman, Mohammad S. (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka) ;
  • Hossain, Mahboob (Department of Pharmacy, The University of Asia Pacific) ;
  • Rashid, Mohammad A. (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka)
  • 발행 : 2008.03.31

초록

The plant Quisqualis indica (Compositae) has ehnopharmcological reputation of being used as a healing agent in Bangladesh. In this study, preliminary screenings were conducted to look at the antimicrobial susceptibility and cytotoxicity of the plant extract. The extractives of the plant were subjected to screening for inhibition of microbial growth by the disc diffusion method. The zones of inhibition demonstrated by the n-hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates of the methanolic extract ranged from 8 - 15 mm, 8 - 18 mm, 12 - 20 mm and 10 - 16 mm, respectively at a concentration of 400 ${\mu}g$/disc. All the extractives were also subjected to brine shrimp lethality bioassay for primary cytotoxicity evaluation. Here, the carbon tetrachloride soluble materials demonstrated the highest cytotoxicity with $LC_{50}$ of 0.826 ${\mu}g$/ml, while n-hexane, chloroform and aqueous soluble partitionates of the methanolic extract revealed the $LC_{50}$ of 1.254, 3.866 and 5.366 ${\mu}g$/ml, respectively. This is the first report of the antimicrobial activity and cytotoxicity Q. indica.

키워드

참고문헌

  1. Bauer AW, Kirby WMM, Sherris JC, Turck M. (1966) Antibiotic susceptibility testing by a standardized single disc method. Am. J. Clin. Pathol. 45, 493-496
  2. Beers MH, Berkow R. (1999) The Merck Manual of Diagnosis and Therapy, Section 13, Chapter 161, Whitehouse Station, NJ: Merck Research Laboratories
  3. De Padua LS, Bunyapraphatsara N, Lemmens RHMJ. (1999) Plant Resources of South-East Asia No. 12(1): Medicinal and Poisonous Plants 1. Source Backhuys Publications, Leiden, the Netherlands, pp. 711
  4. Dictionary of Natural Products, Chapman and Hall, 2002
  5. Ghani A. (2003) Medicinal plants of Bangladesh, Chemical constituents and uses, Asiatic Society of Bangladesh, Dhaka, $2^{nd}$ edition, pp. 363
  6. Karaman I, Sahin F, Gulluce M, Ogutcu H, Sengul M, Adyguzel A. (2003) Antimicrobial activity of aqueous and methanol extracts of Juniperus oxycedrus L. J. Ethnopharmacol. 85, 231-235 https://doi.org/10.1016/S0378-8741(03)00006-0
  7. McLaughlin JL, Rogers LL. (1998) The use of biological assays to evaluate botanicals. Drug Inf. J. 32, 513-524
  8. Meyer BN, Ferrigni NR, Putnam JE, Jacobsen JB, Nicholsand DE, Mclaughlin JL. (1982) Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med. 45, 31-34 https://doi.org/10.1055/s-2007-971236
  9. Persoone G. (1980) Proceeding of the international symposium on brine shrimp, Artemia salina, pp. 1-3, University Press
  10. Rahman S, Hasan CM, Rashid MA, Ilias M. (2001) Pharmacological evaluation of Bangladeshi medicinal plants - a review. Pharm. Biol. 39, 1-6 https://doi.org/10.1076/phbi.39.1.1.5939
  11. Ram AJ, Bhakshu LM, Raju RRV. (2004) In vitro antimicrobial activity of certain medicinal plants from Eastern Ghats, India, used for skin diseases. J. Ethnopharmacol. 90, 353-357 https://doi.org/10.1016/j.jep.2003.10.013
  12. Rashid MA, Hasan CM, Choudhury SAR, Begum B, Rahman S. (1997) Ethnopharmacological investigation of medicinal plants of Bangladesh. Bangladesh J. Physiol. Pharmacol. 12, 25-29
  13. Vanwagenen BC, Larsen R, Cardellina, JH II, Randazzo D, Lidert ZC, Swithenbank C. (1993) Ulosantoin, a potent insecticide from the sponge Ulosa ruetzleri. J. Org. Chem. 58, 335-337 https://doi.org/10.1021/jo00054a013
  14. Welsh SL. (1998) Flora Societensis: A summary revision of the flowering plants of the Society Islands. E.P.S. Inc., Orem, Utah, p. 64
  15. Youn HJ, Noh JW. (2001) Screening of the anticoccidial effects of herb extracts against Eimeria tenella. Vet. Parasitol. 96, 257-263 https://doi.org/10.1016/S0304-4017(01)00385-5