Advances in Traditional Medicine

  • 제7권5호
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  • Pages.540-548
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  • 2008
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Aqueous extract of Paeonia radix suppresses lipopolysaccharide-induced expressions of cyclooygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells

  • Hong, Sung-Kwan (Department of Anatomy-Pointology, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Youn-Sub (Department of Anatomy-Pointology, College of Oriental Medicine, Kyungwon University) ;
  • Yang, Hye-Young (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Chang, Hyun-Kyung (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Yu-Mi (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Shin, Mal-Soon (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Baek, Seung-Soo (Department of Physical Education, College of Arts and Physical Education, Sang Myung University) ;
  • Kim, Chang-Ju (Kohwang Medical Research Institute, Department of Physiology, College of Medicine, Kyung Hee University)
  • 발행 : 2008.02.29
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초록

Paeonia radix is the root of Paeonia aliflora Pallas, which is a perennial plant classified in the family Paeoniaceae. Paeonia radix possesses several pharmacological effects such as analgesic, anti-inflammatory and anti-allergic, anti-oxidative, and anti-coagulant activities. In this study, we investigated the effect of the aqueous extract of Paeonia radix on the lipopolysaccharide-induced inflammation in mouse BV2 microglial cells. The aqueous extract of Paeonia radix at respective concentration was treated one hour before lipopolysaccharide treatment. In the present results, the aqueous extract of Paeonia radix suppressed prostaglandin $E_2$ synthesis and nitric oxide production by inhibiting the lipopolysaccharide-stimulated mRNA expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. These results demonstrate that Paeonia radix exerts anti-inflammatory and analgesic effects probably by suppressing mRNA expressions of cyclooxygenase-2 and inducible nitric oxide synthesis. The present study demonstrates that Paeonia radix may offer a valuable mean of therapy for brain inflammatory diseases.

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