동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제22권2호
  • /
  • Pages.321-327
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  • 2008
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  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

양격산화탕(凉膈散火湯)이 당뇨흰쥐의 전뇌허혈에 미치는 영향

Effects of Yanggyuksanhwa-tang on Global Cerebral Ischemia of Diabetic Rats Induced by Streptozotocin

  • 김의종 (경원대학교 한의과대학 해부경혈학교실) ;
  • 김연섭 (경원대학교 한의과대학 해부경혈학교실)
  • Kim, Eui-Jong (Department of Anatomy-Pointlogy, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Youn-Sub (Department of Anatomy-Pointlogy, College of Oriental Medicine, Kyungwon University)
  • 발행 : 2008.04.25
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초록

This study evaluated neuroprotective effects of Yanggyuksanhwa-tang (YST) on global cerebral ischemia of diabetic rats. On primary experiment, diabetic condition in rats was induced by streptozotocin injection. Secondarily, global cerebral ischemia was induced by bilateral occlusion of the common carotid artery with hypotension (BCAO) under the diabetic condition. Then neuroprotective effect of YST was observed with changes of neuronal c-Fos and Bax expressions, and GFAP expression in the brain tissues by using immunohistochemistry. YST treatment was resulted significant decrease of c-Fos expression in CA1 hippocampus induced by BCAO on diabetic rats. YST treatment was resulted significant decrease of Bax expression in CA1 hippocampus induced by BCAO on diabetic rats. YST treatment was resulted significant decrease of c-Fos expression in cerebral cortex and caudoputamen induced by BCAO on diabetic rats. YST treatment was resulted significant decrease of GFAP expression in cerebral cortex induced by BCAO on diabetic rats. These results suggest that YST has effects on neuroprotection against cerebral ischemic damage under diabetic condition. And it is supposed that neuroprotective effect of YST reveals by anti-apoptosis mechanism.

키워드

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