Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Extracts from Mixed Culture with Tricholoma Matsutake Mycelium and Cordyceps Militaris Mycelium on Blood Glucose in Streptozotocin-Induced Diabetic Rats

송이버섯과 동충하초 균사체 혼합배양 추출물의 투여가 Streptozotocin으로 유발한 당뇨 쥐의 혈당에 미치는 영향

  • Kim, Seong-Sam (Department of College of Oriental Medicin, Wonkwang University) ;
  • Lim, Kyu-Sang (Professional Graduate School of Oriental Medicine, Wonkwang University, Research Center of Traditional Korean Medicine, Wonkwang University) ;
  • kim, Hae-Ja (Department of College of Oriental Medicin, Wonkwang University) ;
  • Chong, Myong-Soo (Department of College of Oriental Medicin, Wonkwang University) ;
  • Cho, Hwa-Eun (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Choi, Yun-Hee (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ki-Nam (Professional Graduate School of Oriental Medicine, Wonkwang University, Research Center of Traditional Korean Medicine, Wonkwang University)
  • 김성삼 (원광대학교 한의학과대학) ;
  • 임규상 (원광대학교 한의학전문대학원, 한국전통의학연구소) ;
  • 김혜자 (원광대학교 한의학과대학) ;
  • 정명수 (원광대학교 한의학과대학) ;
  • 조화은 (원광대학교 한의학전문대학원) ;
  • 최윤희 (원광대학교 한의학전문대학원) ;
  • 이기남 (원광대학교 한의학전문대학원, 한국전통의학연구소)
  • Published : 2008.04.25
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Abstract

This study was performed to investigate the influence of extracts from mixed culture with Tricholoma matsutake mycelium and Cordyceps militaris mycelium on hypoglycemia in streptozotocin-induced diabetic rats. Experimental animals were divided into 7 groups : normal control group(NC), diabetes control group (DC), positive control group(PC), non-fermented OCM(oriental medicine & cereal medium) extracts group (UM), crude polysaccharide of non-fermented OCM extracts group (UME), fermented OCM extracts group (UF), crude polysaccharide of fermented OCM extracts group (UFE). NC, DC groups were orally administered saline, PC group was orally administered acarbose. UM, UME, UF, UFE groups were orally administered each extract once a day for 14days. Blood glucose level was lower in the all administering OCM extract groups (UM, UME, UF, UFE) than in the diabetes group(p<0.05), and specially UF, UFE groups were similar to tendency of PC group. ALT, ALP activity in OCM groups were not significantly lowered than PC group(p<0.05). AST activity was not different with PC group. The results of this study show that extracts from mixed culture with Tricholoma matsutake mycelium and Cordyceps militaris mycelium may have a beneficial effect on the hypoglycemia.

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References

  1. The Bureau of statistics. Statistical annual of mortality cause. p 37, 1996
  2. 許浚. 東醫寶鑑國譯委員會, 對譯東醫寶鑑. 서울, 法仁文化史, p 1331, 1339, 1998
  3. Hillebrand, I., Boehme, K., Frank, G. The effects of the alpha-glucosidase inhibitor BAYg5421(Acarbose) on meal-stimulated elevations of circulating glucose, insulin and triglyceride levels in man. Res Exp Med. 175: 81-86, 1979 https://doi.org/10.1007/BF01851236
  4. Korean Forestry Reports. Reports on the pinemushroom in Korea forest Research Institute, Seoul. Korea. 18: 44-46, 1981
  5. Newman, R.K., Lewis, S.E., Newman, C.W., Boik, R.T., Parnage, R.T. Hypercholesterolmic effect of bareley foods on healthymen. Nutr. Rep. Inc. 39: 749-760, 1989
  6. Oh, H.J., Lee, S.R. physiological function in vitro of beta-glucan isolated from barely. Korean J Food Sci Technol. 28(4):689-695, 1996
  7. Lee, S.E., Kim, D.M., Kim, K.H. Changes in quality of shiitake mushroom(Lentinus edodes) during modified atmoshere storage. J. Korean Soc. Food Nutr. 20: 133-138, 1991
  8. Kim, D.M., Baek, H.H., Yoon, H.H., Lim, K.H. Effect of Co2 concentration in ca condition on the quality of shiitake mushroom(Lentinus edodes) during storage Korean J Food Sci Technol. 21: 461-467, 1989
  9. An, J.S, Lee, K.H. Studies on the mineral contents of Korean mushroom. Korean J Food Hygime and Safty. 1(2):177-179, 1986
  10. Oh, S.W., Kim, C.H., Song, H.N., Han, D.S. Comparative chemical composition of four kinds of tochukaso. Korean J Food Sci Technol. 35(1):15-22, 2003
  11. Beppu, H., Maruta, K., Kumer, T., Kolb, H. Dieabetogenic action of streptozotocin : essential role of membrane permeability. Acta. Endocrinol. (Copdhn) 114: 90-96, 1987
  12. Woo, T.Y., Baek, K.Y., Han, J.P. Effect of royal jelly on therapy and prevention of streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr. 27: 1267-1272, 1998
  13. Shon, K.H., Kim, S.H., Choi, J.W. Pretreatment with nicotinamide to prevent the pancreatic enzymes changes by streptozotocin in rats. J Korean Soc Food Nutr. 21: 117-123, 1992
  14. Harvey, J.N., Jaffa, A.A., Margolium, H.S., Mayfeild, R.K. Renal kallikvein and hemodynamic abnormalities of kidney. Diabetes. 39: 299-304, 1990 https://doi.org/10.2337/diabetes.39.3.299
  15. Kwang, O.G., Yang, J.S., Rhee, S.J. Effects of vitamin E on the anti-oxidative system of kidney in streptozotocin- induced diabetic rats. J Korean Soc Food Nutr. 28(3):654-662, 1999
  16. Lim, S.J., Han, H.K. Hypoglycemic effect of fractions of Cassiatora extract in streptozotocin-induced diabetic rats. J Korean Soc Food Nutr. 13(1):23-29, 1997
  17. Urano, S., Midori, H.H., Tochihi, N., Matsuo, M., Shraki, M. Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics. Lipids. 26: 58-61, 1991 https://doi.org/10.1007/BF02544025
  18. Rho, H.M., Choi, M.A., Koh, J.B. Effects of raw soy enzyme activity in streptozotocin-diabetic rats. J Korean Soc. Food Sci. Nutr. 27: 724-730, 1998
  19. Choi, J.W., Shon, K.H., Kim, S.H. The effects of nicotinamide on the serum lipid composition in streptozotocin-induced diabetic rats. J Korean Soc Food Nutr. 20: 306-311, 1991
  20. Yun, Y.G., Kang, J.S., Seo, D.G. An experimental study on the effect streptozotocin upon the kidney in rats. J Hanyang Med Coll. 11: 155-173, 1991
  21. Kwack, K.H., Kim, S.H., Song, H.J. The effects of yukmijihwang- tang and discoreae radix on the change of blood glucose and serum in diabetic rats induced by alloxan. Kyunghee Med. 8: 388-398, 1993
  22. Kui, N.Y., Oh, H.K. Clinical pathoogy file. 3th ed. Eui-Hak Publishing & Printing Company, Seoul. pp 95-98, 101-102, 1478-1482, 1546-1550, 2000