Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Inhibitory Effect of Rosa laevigata on Nitric Oxide Synthesis and $NF-{\kappa}B$ Activity in lipopolysaccharide-stimulated Macrophages

lipopolysaccharide로 자극된 대식세포에서 금앵자의 Nitric Oxide 생성 및 $NF-{\kappa}B$ 활성 억제 효과

  • Ha, Hyun-Hee (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
  • Park, Sun-Young (Department of Molecular Biology, College of Natural Sciences, Pusan National University) ;
  • Ko, Woo-Shin (Department of Oriental Medicine, College of Oriental Medicine, Dongeui University) ;
  • Jang, Jeong-Su (Central Research Institute, Binex Co. Ltd.) ;
  • Kim, Young-Hee (Department of Molecular Biology, College of Natural Sciences, Pusan National University)
  • 하현희 (부산대학교 자연과학대학 분자생물학과) ;
  • 박순영 (부산대학교 자연과학대학 분자생물학과) ;
  • 고우신 (동의대학교 한의과대학 한의학과) ;
  • 장정수 ((주) 바이넥스 중앙연구소) ;
  • 김영희 (부산대학교 자연과학대학 분자생물학과)
  • Published : 2008.04.25
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Abstract

Nitric oxide (NO) has been suggested to play an important role in endotoxin-mediated shock and inflammation. In this study, we investigated the effect of Rosa laevigata Michx. (Rosaceae) on the production of NO and the molecular mechanism of its action. Rosa laevigata inhibited NO generation and iNOS expression in LPS-stimulated murine macrophages. Activity of nuclear $factor{-\kappa}B\;(NF{-\kappa}B)$ and the degradation of $I{\kappa}B-{\alpha}$ were suppressed by Rosa laevigata. Furthermore, extracellular signal-stimulated kinase (ERK), which is known to be involved in $NF{-\kappa}B$ activation, is inhibited by Rosa laevigata. These results suggest that Rosa laevigata could exert its anti-inflammatory actions by suppressing the synthesis of NO through inhibition of $NF{-\kappa}B$ activity.

Keywords

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