Advances in Traditional Medicine

  • 제8권2호
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  • Pages.146-153
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  • 2008
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Silymarin, a flavonoid antioxidant, protects streptozotocin-induced lipid peroxidation and β-Cell damage in rat pancreas

  • Sharma, Manju (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Anwer, Tarique (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Pillai, K K (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Haque, Syed Ehtaishamul (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Najmi, A K (Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University)) ;
  • Sultana, Yasmin (Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Hamdard University))
  • 발행 : 2008.06.30
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초록

The present study is aimed at finding the influence of silymarin (a flavonoid) (25 mg/kg & 50 mg/kg) in streptozotocin (STZ)-induced diabetic rats. Type 2 diabetes was induced by single intraperitoneal injection of STZ (100 mg/kg) to 3 days old rat pups. Silymarin was administered for 15 days after the animals were confirmed diabetic (75 days after STZ injection). Blood glucose, glycosylated hemoglobin ($HbA_{1c}$), lipid peroxides (LPO) levels and reduced glutathione (GSH) contents in pancreas and liver were estimated following the established procedures. Biochemical observations were further substantiated with histological examination of pancreas. Blood glucose and $HbA_{1c}$ levels, which were elevated by STZ, were lowered to physiological levels by the administration of silymarin. The levels of LPO were significantly increased in STZ-induced diabetic rats. Silymarin reduced the LPO levels in both pancreas and liver. GSH contents which were reduced significantly in pancreas and liver of STZ-induced diabetic rats were brought back to near normal levels by silymarin treatment. Multifocal necrotic and degenerative changes of pancreas in STZ-diabetic rats were minimized to near normal morphology by administration of silymarin as evident by histopathological examination. Silymarin showed a dose dependent protective effect on STZ-induced $\beta$-cell damage. It could be attributed to the antioxidative and free radicals scavenging properties of the flavonoid. Thus, it may be considered as a natural antioxidant with potential therapeutic application in the treatment of type 2 diabetes.

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피인용 문헌

  1. Silibinin decreases hepatic glucose production through the activation of gut–brain–liver axis in diabetic rats vol.9, pp.9, 2018, https://doi.org/10.1039/C8FO00565F
  2. Role of silibinin in the management of diabetes mellitus and its complications vol.41, pp.8, 2018, https://doi.org/10.1007/s12272-018-1047-x