The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Protective Effect of Decursinol on Mouse Models of Sepsis: Enhancement of Interleukin-10

  • Jung, Jun-Sub (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, IDMRC, Hallym University) ;
  • Yan, Ji-Jing (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, IDMRC, Hallym University) ;
  • Song, Dong-Keun (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, IDMRC, Hallym University)
  • Published : 2008.04.30
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Abstract

The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol ($1{\sim}100$ mg/kg) effectively suppressed lethality induced in three mouse models of experimental sepsis, i.e., lipopolysaccharide (LPS)/D-galactosamine (GalN), high-dose LPS (20 mg/kg), and cecal ligation and puncture (CLP). Intra-peritoneal pretreatment of mice with decursinol (50 mg/kg) markedly enhanced the LPS/GalN -induced increase of plasma interleukin-10 (IL-10) levels, without affecting plasma TNF-${\alpha}$, IL-6 and IL-12 levels. These results suggest that decursinol could be effective for prevention or treatment of sepsis.

Keywords

References

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