Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Antidiabetic activity of Diospyros malabarica Kostel bark: a preliminary investigation for possible mode of action

  • Published : 2008.09.30
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Abstract

The defatted methanol extract of bark of Diospyros malabarica (DM) at doses of 200 and 400 mg/kg, p.o. showed significant hypoglycemic activity on normal rats. The extract also exerted significant antihyperglycemic effect in alloxan-induced hyperglycemia and resulted in increase in plasma protein content and decrease in alkaline phosphatase, cholesterol and triglyceride levels when compared with those in the diabetic control group. However there were no significant changes in body and kidney weights of the DM extract-treated animals, compared to those of the untreated diabetic rats as a control. However, the DM extract showed a potential antioxidant activity by increasing catalase activity and reducing lipid peroxidation in liver. The results demonstrate antidiabetic activity of the defatted methanol extract of DM bark.

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References

  1. Ader R. (1984) Breakdown in human adaptation to stress, pp. 563-580, Martinus Ninjhoff, Boston
  2. Amos AF, McCarty DJ, Zimmet P. (1997) The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet. Med. 14, S1-85 https://doi.org/10.1002/(SICI)1096-9136(199712)14:5+3.0.CO;2-R
  3. Chattopadhyay S, Ramanathan M, Das J, Bhattacharya SK. (1997) Animal models in experimental diabetes mellitus. Indian J. Exp. Biol. 35, 1141-1145
  4. Chopra RN, Chopra IC, Handa KL, Kapur LD. (1994) Chopra's Indigenous drugs of India, $2^{nd}$ ed. pp. 505, Academic Publishers, Cacutta, India
  5. Choudhary DN, Singh JN, Verma SK, Singh BP. (1990) Antifertility effects of leaf extracts of some plants in male rats. Indian J. Exp. Biol. 28, 714-718
  6. Dhanabal SP, Koate CK, Ramanathan M, Elango K, Suresh B. (2004) The hypoglycemic activity of Coccinia indica Wight & Arn. And its influence on certain biochemical parameters. Indian J. Pharmacol. 36, 244-250
  7. Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. (1968) Screening of Indian plants for biological activity: part I. Indian J. Exp. Biol. 6, 232-247
  8. Grover JK, Yadav SP, Vats V. (2003) Effect of feeding Murraya koeingii and Brassica juncea diet kidney functions and glucose levels in streptozotocin diabetic mice. J. Ethnopharmacol. 85, 1-5 https://doi.org/10.1016/S0378-8741(02)00355-0
  9. Gupta RK, Tiwari RD. (1964) Chemical examination of the leaves of Diospyros peregrina Gurke. Indian J. Chem. 2, 129-130
  10. Halliwell B, Gutteridge JMG. (1989) Free radicals in Biology and Medicine, pp. 215, Clarendon Press, Oxford
  11. Iwu MM. (1980) Antidiabetic properties of Bridelia ferruginea leaves. Planta Med. 39, 247-252
  12. Iwu MM. (1983) The hypoglycaemic properties of Bridelia Ferruginea. Fitoterapia 54, 243-248
  13. Kadnur SV, Goyal RK. (2005) Comparative antidiabetic activity of different fractions of methanolic extract of Zingiber officinale Roscoe in streptozotocin induced NIDDM rats. Orient. Pharm. Exp. Med. 5, 201-208
  14. King H, Aubert RE, Herman WH. (1998) Global Burden of Diabetes, 1995-2025. Diabetes care 21, 1414-1431 https://doi.org/10.2337/diacare.21.9.1414
  15. Kirtikar KR, Basu BD, Ann ICS. (1975) Indian medicinal plants. Vol 2, $2^{nd}$ ed. pp. 1502-1525, M/s Bishen Singh Mehendra Pal Singh
  16. Krishnakumar K, Augusti KT, Vijayammal PL. (1999) Hypoglycemic and antioxidant activity of Salacia oblonga Wall. extract in streptozotocininduced diabetic rats. Indian J. Physiol. Pharmacol. 43, 510-514
  17. Lata H, Ahuja GK. (2003) Role of free radicals in health and disease. Indian J. Physiol. All. Sci. 57, 124-132
  18. Litchfield JT, Wilcoxon FA. (1949) Simplified method of evaluating dose effect experiments. J. Pharmacol. Exp. Ther. 96, 99-133
  19. Luck H. (1971) Methods of enzymatic analysis. Vol. 3, pp. 885-890, Academic Press, New York
  20. Misra PS, Misra G, Nigam SK. (1971) Constituents of Diospyros peregrine fruit and seed. Phytochemistry 10, 904-905 https://doi.org/10.1016/S0031-9422(00)97175-9
  21. Mondal SK, Chakraborty G, Gupta M, Mazumder UK. (2005) Hepatoprotective activity of Diospyros malabarica bark in carbon tetrachloride intoxicated rats. Eur. Bull. Drug Res. 13, 25-30
  22. Mondal SK, Chakraborty G, Gupta M, Mazumder UK. (2006) In vitro antioxidant activity of Diospyros malabarica Kostel bark. Indian J. Exp. Biol. 44, 39-44
  23. Nikkila EA, Kekki M. (1973) Plasma triglyceride transport kinetics in diabetes mellitus. Metabolism 22, 1-22 https://doi.org/10.1016/0026-0495(73)90024-3
  24. Ohkawa H, Onishi M, Yagi K. (1979) Assay for lipidperoxidation in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358 https://doi.org/10.1016/0003-2697(79)90738-3
  25. Prince PSM, Menon VP. (2003) Hypoglycemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats. Phytother. Res. 17, 410-413 https://doi.org/10.1002/ptr.1130
  26. Raghunathan M, Raghunathan N. (1992) Diabetes mellitus and Vitamin D, Nutrition News.13, 4
  27. Rahman AU, Zaman K. (1989) Medicinal plants with hypoglycaemic activity. J. Ethnopharmacol. 26, 1-55 https://doi.org/10.1016/0378-8741(89)90112-8
  28. Rasch R. (1979) Prevention of diabetic glomerulopathy in streptozotocin induced diabetic rats by insulin treatment. Kidney size and glomerular volume. Diabetologia 16, 124-128 https://doi.org/10.1007/BF01225462
  29. Shanmugasundaram KR, Paneerselvam C, Samudram P, Shanmugasundaram ERB. (1983) Enzyme changes in glucose utilization in diabeteic animals: the effect of Gymnema sylvestre R.Br. J. Ethnopharmacol. 7, 205-234 https://doi.org/10.1016/0378-8741(83)90021-1
  30. Sheela CG, Augusti KT. (1992) Antidiabetic effects of S-allyl cysteine sulfoxide isolated from garlic Allium sativum. Indian J. Exp. Biol. 30, 523-526
  31. Taskimen MR. (1987) Lipoprotein lipase in diabetes, Diabetes Metab. Rev. 3, 551-570
  32. Trinder P. (1969) Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann. Clin. Biochem. 6, 24-27
  33. Tripathi KD. (2004) Essentials of Medical Pharmacology, pp 245-252, Jaypee Brothers Medical Publishers Pvt Ltd, New Delhi, India
  34. Vander AJ, Sherman JH, Luciano DS. (1990) Defence mechanism of the body: Immunology, Foreign chemicals and Stress. In: Human Physiology-The mechanisms of body functions, 5th ed, p 274, McGraw Hill Ryerson, Canada
  35. Vasu VT, Ashwinikumar C, Maroo J, Gupta S, Gupta S. (2003) Antidiabetic effect of Enicostemma littorale Blue aquous extract in newly diagnosed non-insulin dependent diabetes mellitus patients (NIDDM): A preliminary investigation. Orient. Pharm. Exp. Med. 3, 84-89
  36. Vishwakarma SL, Rajani M, Goyal RK. (2003) Comparative antidiabetic activity of different fractions of Enicostemma littorale Blue in streptozotocin induced NIDDM rats. Orient. Pharm. Exp. Med. 3, 196-204
  37. Yadav S, Vats V, Dhunnoo Y, Grover JK. (2002) Hypoglycemic and antihyperglycemic activity of Murraya koenigii leaves in diabetic rats. J. Ethnopharmacol. 82, 111-116 https://doi.org/10.1016/S0378-8741(02)00167-8