Advances in Traditional Medicine

  • 제8권3호
  • /
  • Pages.311-315
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  • 2008
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Antihyperlipidemic effects of alcoholic extract of Pongamia pinnata Linn. leaves on high fat diet fed rats

  • Tenpe, CR (Department of Pharmacology, Institute of Pharmaceutical Education and Research) ;
  • Mane, G (Department of Pharmacology, Institute of Pharmaceutical Education and Research) ;
  • Upaganlawar, AB (Department of Pharmacology, Institute of Pharmaceutical Education and Research) ;
  • Ghule, BV (Department of Pharmacology, Institute of Pharmaceutical Education and Research) ;
  • Yeole, PG (Department of Pharmacology, Institute of Pharmaceutical Education and Research)
  • 발행 : 2008.09.30
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초록

The objective of the study was to investigate the antihyperlipidemic activity of alcoholic extract of Pongamia pinnata Linn. (PPAE) leaves in rats fed with high fat diet (HFD). PPAE was administered orally in the divided doses of 250 and 500 mg/kg/day for 30 days in HFD fed rats. Body weights were observed and the analysis of serum lipid profile was carried out on day 30. Marked decrease in the body weight, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) whereas significant increase in the levels of high density lipoprotein (HDL) were observed after treatment with PPAE. However, PPAE in a dose of 250 mg/kg did not show significant (P < 0.05) increase in HDL levels. The PPAE also lowered TC: HDL-c and LDL: HDL-c ratios significantly suggesting it's antihyperlipidemic and cardioprotective potential. The present work reveals that PPAE at the dose of 500 mg/kg/day exhibited significant (P < 0.01) antihyperlipidemic effects.

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참고문헌

  1. Ahmad G, Yadav PP, Maurya R. (2004) Furoflavonoid glycosides from Pongamia pinnata fruits. Phytochemistry 65, 921-924 https://doi.org/10.1016/j.phytochem.2004.01.020
  2. Babu V, Gangadevi T. (2002) Antihyperglycemic activity of Cassia Kleinii leaf extract in glucose fed normal rats and alloxan induced diabetic rats and isolation of an active fraction and toxicity evaluation of the extract. Indian J. Pharmacol. 34, 409-415
  3. Bainton D, Miller NE, Botton CH, Yarnell JWG, Suretman PM, Baker LA, Lewis B, Elwood PC. (1992) Plasma triglycerides and high density lipoprotein cholesterol as predictors of ischemic heart disease in British man. Br. Heart J. 68, 60-66 https://doi.org/10.1136/hrt.68.7.60
  4. Basarkar PW, Nath N. (1983) Hypocholesteramic and hypolipidemic effect of Quercetin- a Vitamine P like compound in rats. Indian J. Med. Res. 77, 122-126
  5. Brown MS, Goldstein JL. (1990) Drugs used in the treatment of hyperlipoproteinemia. In Goobman and Gilman's Pharmacological basis of therapeutics, Gilman AG, Rall TW, Nives AS, Taylor PA (ed): Maxwell Macmillan, International Edition, Bengmon Press, p. 874. New York
  6. Chan PT, Fonf WP, Cheung YL, Huang Y, Ho WK, Chen ZY. (1999) Jasmine green tea epicatechins are hypolipidemic in hamsters fed a high fat diet. J. Nutr. 129, 1094-1101
  7. Dhuley JN, Naik SR, Refe S. (1999) Hypolipedimic and antioxidant activity of diallyl disulphide in rats. Pharm. Pharmacol. Commun. 5, 689-696
  8. Friedwald WT, Levy RI, Freidrickson DS. (1972) Estimation of LDL-Cholesterol in Plasma without preparation of ultra centrifuge. Clin. Chem. 18, 449-502
  9. Guimaraes PR, Galavao AMP, Batista CM, Azovedo GS, Oliveira RD, Lamounier RP, Frieire NB, Sakurai E, Olivera JP, Vieira EC, Aalvarez JI. (2000) Eggplant (Solanum melongena) infusion has modest and transitory effect on hypercholesteremic subjects. Braz. J. Med. Biol. Res. 33, 1027-1036 https://doi.org/10.1590/S0100-879X2000000900006
  10. Harrison D, Kathy KG, Hornig B, Drexler H. (2003) Role of oxidative stress in atherosclerosis. Am. J. Cardiol. 91, 7A-11A https://doi.org/10.1016/S0002-9149(02)03144-2
  11. Inoue M, Wu CZ, Dou DQ, Chen YZ, Ogihara Y. (1999) Lipoprotein lipase activation by red ginseng saponin in hyperlipidemia animal model. Phytomedicine 6, 257-265
  12. Joseph L, Witztum K. (1996) The pharmacological basis of therapeutics, McGrowill Health Professions division, p. 875
  13. Kirtikar KR, Basu BD. (1995) Indian Medicinal Plants (International Book Distributors). Dehradune, India
  14. Sidhu GS, Oakenful DG. (1986) A mechanism for the hypocholesterolaemic activity of saponins. Br. J. Nutr. 55, 643-649 https://doi.org/10.1079/BJN19860070
  15. Simons LA. (2002) Additive effect of plant sterol ester margarine and cervastatin in lowering low density lipoprotein cholesterol in primary hypercholesterolemia. Am. J. Cardiol. 90, 737-740 https://doi.org/10.1016/S0002-9149(02)02600-0
  16. Srinivasan K, Muruganandan S, Lal J. (2001) Evaluation of anti-inflammatory activity of Pongamia pinnata leaves in rats. J. Ethanopharmacol. 78, 151-157 https://doi.org/10.1016/S0378-8741(01)00333-6
  17. Talpatra SK, Malik AK, Talpatra B. (1980) Pongaglabol, a new hydroxyfuroflavone and aurantiamide acetate, a dipeptide from the flower of Pongamia glabra. Phytochemistry 19, 1199-1202 https://doi.org/10.1016/0031-9422(80)83083-4
  18. Treasure IB, Klein JL, Weintraub WS, Talley SD. (1995) Beneficial effect of cholesterol lowering therapy on the coronary endothelium in patients with coronary artery disease. N. Engl. J. Med. 8, 481-487 https://doi.org/10.1056/NEJM199502233320801
  19. Wilson PWF. (1990) High density lipoprotein, low density lipoprotein and coronary heart disease. Am. J. Cardiol. 66, 7A-10A https://doi.org/10.1016/0002-9149(90)90562-F