It was said that the epigastric region was the outbreak region of chest bind on Shanghanlon. But successive medical men annotated the epigastric region as the chest, which caused the misunderstanding that chest bind was a chest trouble. However Youzaijing, a medical man in Qing dynasty, presented that the epigastric region meant stomach and the middle of stomach did intestines, comparing Dachengqi-tang with Daxianxiong-tang. This view agreed with Huatuo's six-region-transmutation theory. Taojiean and Zhangjingyue also criticized on the six-meridian-transmutation theory, proposing that the change of cold damage didn't go by the fixed rules. This reflected the oriental medical pathologic view that pathogen invaded and advanced to the weak region by the relations between healthy qi and pathogen, and it criticized on the doctrinarian interpretation of Shanghanlon as Neijing. Huatuo insisted that stomach was the final stage of cold damage by presenting that theory. And this theory became a philological basis on Youzaijing's pathologic view.