Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Eucommia Ulmoides Oliver and Treadmill Exercise on the Osteoporosis of Rats Caused by Glucocorticoid Induction

두충 추출물 투여와 트레드밀 운동이 골다공증 유발 백서의 골대사에 미치는 영향

  • Yoon, Seok-Joo (Department of Physical Therapy, Dongshin University) ;
  • Kim, Kyung-Yoon (Department of Physical Therapy, Dongshin University) ;
  • Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University) ;
  • Nam, Ki-Won (Department of Physical Therapy, Dongshin University) ;
  • Sim, Ki-Cheol (Department of Physical Therapy, Dongshin University) ;
  • Kim, Eun-Jung (Department of Physical Therapy, Dongshin University) ;
  • Chung, Hun-Woo (Department of Oriental Medicine, Dongshin University) ;
  • Kim, Hyung-Woo (Department of Oriental Medicine, Dongshin University) ;
  • Kim, Gi-Do (Department of Physical Therapy, Dongshin University)
  • Published : 2008.08.25
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Abstract

This study classified 40 of 10 weeks-old male Sprague Dawley rats which have osteoporosis caused by glucocorticoid(GC) induction into four groups of 10 rats and made the subjects medicated them Eucommia ulmoides Oliver and participate in treadmill exercise. Group I was non-treatment after GC induction; Group II was treadmill exercise after GC induction; Group III was Eucommia ulmoides Oliver feeding after GC induction; Group IV was treadmill exercise and Eucommia ulmoides Oliver feeding after GC induction. In the bone mineral density and bone strength test, there was a statistically significant difference between the group I, II, III compared to group IV(p<0.05). In the osteocalcin level as one of bone formation indexes, there was a statistically significant difference between the group I, II, III compared to group IV(p<0.05). In respect to the calcium there was a statistically significant difference between group I, II, III compared to group IV(p<0.05). In respect to histological findings, the group IV showed mild femur disruption and lytic change on femur section. The above results suggests that Eucommia ulmoides Oliver medicated and treadmill exercise is effective to prevention and treatment of osteoporosis.

Keywords

References

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