Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Endoscopy Finding of Patients Who Complained of the Upper Digestive Symptoms after Taking Oriental Herb Decoctions

  • Kim, Dong-Woung (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • Published : 2008.08.25
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Abstract

This study was carried out to understand the macroscopic aspects of the digestive system symptoms occurring after taking oriental herb complex decoction as observing morphological changes in esophagus, stomach and duodenal bulb by endoscopy of upper gastrointestinal tract when these symptoms developed. The subjects of this study were 46 patients (male 22, female 24, mean age : $54.72{\pm}14.26$ years) who were chosen among ones who took oriental herb complex decoction for medical care and developed symptoms related to the gastrointestinal tract while taking an oriental herb decoction, which were assumed that the digestive symptoms were newly developed because of administration. The subjects were given morphological examination by endoscopy of the upper gastrointestinal tract. As a result of the endoscopy operated due to the digestive symptoms developed during the administration of oriental herb decoction, there were 2 cases of esophagitis, 5 cases of acute gastritis, 1 case of chronic gastritis A type, 15 cases of chronic gastritis B type, 1 case of duodenitis, 1 case of gastric ulcer, 1 case of gastric polyp, 2 cases of intestinal metaplasia, 1 case of gastric ptosis and 17 cases of normal findings which didn't have any abnormality macroscopically with endoscopy. With regards to the patients who complained of the digestive symptoms after taking oriental herb decoction, it has been found that the symptoms occurred as the oriental herbal medicine taken by the patients who had the digestive symptoms at ordinary times influenced on the gastrointestinal tract. Especially, many of them were had chronic gastritis and functional dyspepsia in the past. The disease accompanying macroscopic lesions at endoscopy which occurred due to the oriental herb decoction as direct cause, was acute gastritis, and it was the prescription to cure the pains and inflammations of skeletomuscular disease.

Keywords

References

  1. Huang Taikang. A handbook of the composition and pharmacology of common chinese drug. Chines science and technics publishing, Beijing, China, 1994
  2. Lichtenstein, D.R., Syngal, S., Wolfe, M.M. Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract, the double-aged sword. Arthritis Rheum 38: 5-18, 1995 https://doi.org/10.1002/art.1780380103
  3. Fries, J., Williams, C.A., Bloch, D.A., Michael, B.A. Nonsteroidal anti-inflammatory drug-associated gastropathy: incidence and risk factor models, Am J Med 91: 213-222, 1991 https://doi.org/10.1016/0002-9343(91)90118-H
  4. Wolfe, M.M., Lichtenstein, D.R., Singh, G. Gastrointestinal toxicity of Nonsteroidal anti-inflammatory drugs. N Engl J Med 340: 1888-1899, 1999 https://doi.org/10.1056/NEJM199906173402407
  5. Bombardier, C., Laine, L., Reicin, A. Comparion of upper intestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med. 343: 1520-1528, 2000 https://doi.org/10.1056/NEJM200011233432103
  6. Silverstein, F., Faich, G., Goldstein, J.L. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis. The CLASS study: a randormized controlled trial. JAMA. 284: 1247-1255, 2000 https://doi.org/10.1001/jama.284.10.1247
  7. Bombardier, C., Laine, L., Reicin, A. et al. Comparison of upper intestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med. 343: 1520-1528, 2000 https://doi.org/10.1056/NEJM200011233432103
  8. Lee, E.L., Feldmann, M. Gastritis and other gastropathies. In : Feldmman, M., Friedman, L.S., Sleigenger, M.H. eds. Sleigenger & Fordtran's gastrointestinal and liver disease. 7th edition. WB Saunders Company, Philadelphia, USA. pp 810-827, 2002
  9. J.J. Jeong, M.G. Choi, H. Choi, J.M. Park, J.H. Oh, E.J. Jeon, B.I. Lee, I.S. Lee, S.W. Kim, S.W. Choi, G.Y. Choi, I.S. Chung. Single blind, randomized, active drug comparative, multi-center study to evaluate the therapeutic efficacy of $Gliptide{\circledR}$ Tab (sulglycotide 200 mg) in gastritis patients: phase IV study. Korean J Gastrointest Endosc 35: 125-132, 2007
  10. Yoshikawa, T., Naito, Y. The role of neutrophils and inflammation in gastric mucosal injury. Free rad Res. 33: 785-794, 1999 https://doi.org/10.1080/10715760000301301
  11. Spechler, S.J. Peptic ulcer and its complications. In : Feldmman, M., Friedman, L.S., Sleigenger, M.H. eds. Sleigenger & Fordtran's gastrointestinal and liver disease. 7th edition. WB Saunders Company, Philadelphia, USA. pp 747-781, 2002
  12. Isenberg, J.I., Hogan, D.L., Koss, M.A., Selling, J.A. Human duodenal mucosal bicarbonate secretion. Evidence for secretion and stimulation by hydrochloric acid and a synthetic prostaglandin E1 analogue. Gastroenterology. 91: 370, 1986 https://doi.org/10.1016/0016-5085(86)90571-8
  13. Laine, L., Cohen, H., Sloane, R., Marin-Sorensen, M., Weinstein, W.M. Inter-observer agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers. Gastrointest Endosc 42: 420-423, 1995 https://doi.org/10.1016/S0016-5107(95)70043-9
  14. Dennis, L., Kasper Anthony, S., Fauci Dan, L., Longo, E., Braunwald Stephen, L., Hauser, T., Larry Jameson. Principle of Internal Medicine, 16th edition. Macgraw Hill Companies, New York, USA, pp 1746-1755, 2005
  15. Lee Goldman, Dennis Ausiello. Cecil Text Book of Internal Medicine, 22th edition. Saunders Elsevier, New York, USA, pp 823-824, 2004
  16. Graham, D.Y., Lew, G.M., Klein, P.D., Evans, D.G., Evans, D.J.Jr., Saeed, Z.A., Malaty, H.M. Effects of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer: a randomized controlled study. Am Intern Med. 116: 705-708, 1992 https://doi.org/10.7326/0003-4819-116-9-705
  17. Guarner, J., Herrera, G.R., Mohar, A., Sanchez, L., Halperin, D., Ley, C., Parsonnet, J. Gastric atrophy and extent of intestinal metaplasia in a cohort of Helicobacter pylori-infected patients. Human pathology. 32(1):31-35, 2001 https://doi.org/10.1053/hupa.2001.20889
  18. Craanen, M.E., Dekker, W., Blok, P., Ferwerda, J., Tytgat, G.N. Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum. Gut. 33: 16-20, 1992 https://doi.org/10.1136/gut.33.1.16
  19. Feinle-Bisset, C., Vozzo, R., Horowitz, M., Talley, N.J. Diet, food intake, and disturbed physiology in the pathogenesis of symptoms in functional dyspepsia. Am J Gastroenterol. 98: 170-181, 2003 https://doi.org/10.1111/j.1572-0241.2003.08243.x
  20. J.S. Kim., K.J. Lee., J.H. Kim., K.B. Nah., S.W. Cho. Functional gastrointestinal disorders in patients referred to specialist gastroenterologists in a tertiary hospital. Kor J Neurogastroenterol Motil. 10: 111-117, 2004
  21. Mertz, H., Fullerton, S., Nailboff, B., Mayer, E.A. Symptoms and visceral perception in severe functional and organic dyspepsia. Gut. 42: 814-822, 1988 https://doi.org/10.1136/gut.42.6.814
  22. Baker, G., Hraser, RJ., Young, G. Subtypes of functional dyspepsia. World J Gastroenterol. 12: 2667-2671, 2006 https://doi.org/10.3748/wjg.v12.i17.2667
  23. Barbera, R., Feinle, C., Read, N.W. Abnormal sensitivity to duodenal lipid infusion in patients with functional dyspepsia. Eur J Gastroentrol Hepatol. 7: 1051-1057, 1995 https://doi.org/10.1097/00042737-199511000-00007