Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Houttuynia cordata Thunb and Herbs Mixture Extract on the Lipid Metabolism in the LPS-induced Hepatotoxicity

어성초 함유 혼합추출물이 LPS 유도 간독성에서 지질대사에 미치는 영향

  • Kwon, Ryun-Hee (Department of Public Health, Graduate School of Public Health and Welfare, Konyang University) ;
  • Na, Bak-Ju (Department of Preventive Medicine, College of Medicine, Konyang University) ;
  • Park, Si-Jun (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Mun, Yeun-Ja (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Woo, Won-Hong (Professional Graduate School of Oriental Medicine, Research Center of Traditional Korean Medicine, Wonkwang University) ;
  • Lee, Moo-Sik (Department of Preventive Medicine, College of Medicine, Konyang University)
  • 권륜희 (건양대학교 보건복지대학원 보건학과) ;
  • 나백주 (건양대학교 의과대학 예방의학교실) ;
  • 박시준 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과, 원광대학교 한국전통의학연구소) ;
  • 이무식 (의과대학 예방의학교실)
  • Published : 2008.06.25
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Abstract

Lipopolysaccharide (LPS) induces the synthesis of several inflammatory cytokine, chemokine, NO and inflammation in the liver of rats. The purpose of this study was to investigate the preventive effects of Houttuynia cordata Thunb and Oriental herbs mixture extract (HCTM) against the hepatotoxicity-inducing LPS in the lipid metabolism. HCTM of 100 mg/kg concentration was intra-peritoneally administered into rats at dose of 1.5 ml/kg for 20 days. On the day 21, 1.5 ml/kg of LPS was injected 4 hours before anesthetization. The levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), total lipid, triglyceride (TG) and HDL-cholesterol (HDL-C) were measured in serum. LPS-treatment markedly increased the levels of GOT, GPT, total lipid and TG, and decreased the level of HDL-C. However, HCTM pretreatment decreased the levels of GOT, GPT, total lipid and TG by 76.8%, 55.48%, 34.04% and 76.21% respectively, and increased the level of HDL-C by 97.84%. These results showed that HCTM had the protective effect against the hepatotoxicity-inducing LPS in the lipid metabolism, and it suggest that HCTM could be used for functional beverage.

Keywords

References

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