동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제22권3호
  • /
  • Pages.642-648
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  • 2008
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

체감의이인탕(體減薏苡仁湯)의 항비만 효과 연구

Study on Anti-obesity Effect of Chegameuiin-tang

  • 박태용 (원광대학교 한의과대학 한방재활의학교실) ;
  • 신병철 (원광대학교 한의과대학 한방재활의학교실) ;
  • 공재철 (원광대학교 한의과대학 한방재활의학교실) ;
  • 송미영 (전북대학교 의과대학 생화학교실) ;
  • 김은경 (전북대학교 의과대학 생화학교실) ;
  • 서은아 (원광대학교 생활과학대학 식품영양학과) ;
  • 류도곤 (원광대학교 한의과대학 한방생리학교실) ;
  • 권강범 (원광대학교 한의과대학 한방생리학교실)
  • Park, Tae-Yong (Department of Oriental Rehabilitation, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Byung-Cheul (Department of Oriental Rehabilitation, College of Oriental Medicine, Wonkwang University) ;
  • Kong, Jae-Cheol (Department of Oriental Rehabilitation, College of Oriental Medicine, Wonkwang University) ;
  • Song, Mi-Young (Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University) ;
  • Kim, Eun-Kyung (Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University) ;
  • Seo, Eun-A (Department of Food and Nutrition, School of Human Envioronmental Science, Wonkwang University) ;
  • Ryu, Do-Gon (Department of Physiology, College of Oriental Medicine, Wonkwang University) ;
  • Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
  • 발행 : 2008.06.25
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초록

The aim of this study is to investigate Chegameuiin-tang water extracts (CETE) have potent anti-obesity activities in a high fat diet-induced obesity mouse model. In this study, we designed three group (normal diet group, high fat diet group, high fat diet plus CETE group for 13-week oral administration). Increases in body weight and fat storage were inhibited by 13-week oral administration of CETE at a 500 mg/kg concentration in this animal model, while the amount of food intake was not affected. Results from blood lipid analysis showed that the levels of triglyceride, total cholesterol and LDL-cholesterol were significantly lowered by CETE administration, also HDL-cholesterol was increased more than high fat diet-induced obese mouse. To understand the underlying mechanism at the molecular level, the effects of CETE were examined on the expression of the genes involved in lipogenesis and lipolysis by real-time PCR. In epididymal fat of CETE-treated mice, the mRNA level of lipogenic genes such as sterol regulatory element binding protein 1 and fatty acid synthase were decreased, which was well correlated with the reduction of the epididymal fat weight. Also, CETE administration inhibited decreases of the hormone-sensitve lipase and lipoprotein lipase mRNA expressions, which are genes related with lipolysis. These results suggest that Chegameuiin-tang may have great potential as a novel anti-obesity agent.

키워드

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