Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effect of Sorbus cortex Extract on (1,3)-$\beta$-Glucan Synthase

정공피 추출물의 (1,3)$\beta$-Glucan Synthase에 대한 억제효과

  • You, Myung-Ja (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University) ;
  • Kim, Bo-Mi (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University) ;
  • Lee, Jeong-Ho (Department of Natural Health Management, Songho College) ;
  • Lee, Young-Hang (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University) ;
  • Chai, Kyu-Yun (Division of Nanobiochemistry, College of Natural Sciences, Wonkwang University) ;
  • Baek, Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 유명자 (원광대학교 자연과학대학 생명나노화학부) ;
  • 김보미 (원광대학교 자연과학대학 생명나노화학부) ;
  • 이정호 (송호대학 자연건강관리과) ;
  • 이영행 (원광대학교 자연과학대학 생명나노화학부) ;
  • 채규윤 (원광대학교 자연과학대학 생명나노화학부) ;
  • 백승화 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2008.10.25
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Abstract

A examination of the kinetic properties of UDP-glucose : (1,3)-$\beta$-glucan (callose) synthase from mung bean seedings (Sorbus cortex) shows that these enzymes have a complex interaction with UDP-glucose and various effectors. Deoxynojirimycin increased the inhibitory effect of (1,3)-$\beta$-glucan synthase at the concentration-dependent manner by fluorescence assay. The inhibitory effect of Fr. 2-16 (97.15%) showed higher than that of deoxynojirimycin (80.63%). Fr. 2-3 inhibited the growth of the Candida albicans at 1 mm inhibition zone by disk diffusion method. These results suggest that Sorbus cortex extract can be used as a stable antifungal material.

Keywords

References

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