Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Antidementia Effect of Jangwonhwangagambang Water Extract in APP-induced Drosophila Model

장원환가감방(壯元丸加減方) 전탕액(煎湯液)이 APP로 유도된 형질전환 초파리에서의 항치매 효과

  • Han, Won-Ju (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Sang-Tae (Division of BioScience-Pharmacy, Ewha Womans University) ;
  • Lee, Chung-Sik (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Park, Bo-Ra (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Jung, Eun-Young (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Dae-Hyun (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Yun, Jong-Hyun (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Jin-Woo (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Kang, Hyung-Won (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Lyu, Yeoung-Su (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Tae-Heon (Department Neuropsychiatry, College of Oriental Medicine, Wonkwang University)
  • 한원주 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김상태 (이화여자대학교 생명.약학부 뇌신경연구실) ;
  • 이충식 (원광대학교 한의과대학 신경정신과학교실) ;
  • 박보라 (원광대학교 한의과대학 신경정신과학교실) ;
  • 정은영 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김대현 (원광대학교 한의과대학 신경정신과학교실) ;
  • 윤종현 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김진우 (원광대학교 한의과대학 신경정신과학교실) ;
  • 강형원 (원광대학교 한의과대학 신경정신과학교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과학교실) ;
  • 김태헌 (원광대학교 한의과대학 신경정신과학교실)
  • Published : 2008.10.25
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Abstract

Recent studies indicate that the deposition of ${\beta}$-amyloid ($A{\beta}$) is associated with the pathogenesis of Alzheimer's disease (AD), but the underlying mechanism is not clear yet. To investigate the effects of Jangwonhwangagambang (JWHG) extract on AD pathogenicity, we have generated transgenic Drosophila model in which GMR-APP-GAL4/UAS-GRIM system was designed to overexpress amyloid precursor protein(APP), We examined fly's survival ratio, flight behavior, and morphological patterns of chest and eye. We found that JWHG treatment improved fly's survival ratio by inhibiting apoptosis and flight behavior. APP-GRIM transgenic flies treated with JWHG showed had significantly lower levels of APP deposition in the chest and eye compared to control animals. JWHG treatment further inhibited chest and eye degeneration. These results suggest that JWHG prevents APP-induced neurotoxicity, and thus may be applicable for the development of preventive or therapeutic agents for AD treatment.

Keywords

References

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