Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-hypertensive Activity of New Potato(Solanum tuberosum) Variety of Gui Valley Via Inhibition of Angiotensin Converting Enzyme

안지오텐신 전환효소활성 저해에 의해 항고혈압 효과를 갖는 신품종 감자 구이벨리 추출물

  • Kim, Kwan-Hyun (Cancer Preventive Material Development Research Center, Kyunghee University) ;
  • Kim, Sun-Hee (Cancer Preventive Material Development Research Center, Kyunghee University) ;
  • Lee, Eun-Ok (Cancer Preventive Material Development Research Center, Kyunghee University) ;
  • Kwon, Hyun-Jung (Cancer Preventive Material Development Research Center, Kyunghee University) ;
  • Choi, Jong-Won (College of Pharmacy, Kyungsung University) ;
  • Lim, Hak-Tae (Potato valley Co., Ltd & Kangwon National University) ;
  • Kim, Sung-Hoon (Cancer Preventive Material Development Research Center, Kyunghee University)
  • 김관현 (경희대학교 암예방소재개발연구센터) ;
  • 김선희 (경희대학교 암예방소재개발연구센터) ;
  • 이은옥 (경희대학교 암예방소재개발연구센터) ;
  • 권현정 (경희대학교 암예방소재개발연구센터) ;
  • 최종원 (경성대학교 약학대학) ;
  • 임학태 ((주) 포테이토밸리 & 강원대학교 생명공학부) ;
  • 김성훈 (경희대학교 암예방소재개발연구센터)
  • Published : 2009.02.25
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Abstract

This study was attempted to investigate the anti-hypertensive activity of Solanum tuberosum, cv. Gui valley. Ethanol extract of Gui vally (EGV) increased free radical scarvenge activity up to 91.6% of control at $200{\mu}g/m{\ell}$. It's anti-oxidant activity is similar to 10 uM of ascorbic acid, well known as antioxidant. EGV inhibited Angiotensin-I-converting enzyme (ACE) activity in vitro. ACE plays a important role in regulation of blood pressure and ACE inhibitors are important for the treatment of hypertension. Anti-hypertensive activity of EGV in vivo was assessed in lead acetate (LAT)-induced hypertensive rats for 8 weeks. Elevated blood pressure in control group was significantly decreased by EGV at 200 mg/kg. Also, ACE activity in blood was also suppressed by EGV treatment. Taken together, these results suggest that EGV has an anti-hypersive activity via inhibition of ACE and can be used for the treatment or prevention of hypertension.

Keywords

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