Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia

  • Hong, Hee-Ok (Department of Food Service Management and Nutrition, Sangmyung University) ;
  • Kim, Chun-Soo (Department of Food and Nutrition, Chung-Ang University) ;
  • Maeng, Sung-Ho (Maria Biotech Co.)
  • Published : 2009.12.31
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Abstract

This study was to investigate the role of complementary and alternative medicine in the prevention and treatment of benign prostatic hyperplasia. For this purpose, a randomized, double-blind, placebo-controlled trial was performed over 12 months on 47 benign prostatic hyperplasia patients with average age of 53.3 years and international prostate symptom score over 8. Subjects received either sweet potato starch (group A, placebo, 320 mg/day), pumpkin seed oil (group B, 320 mg/day), saw palmetto oil (group C, 320 mg/day) or pumpkin seed oil plus saw palmetto oil (group D, each 320 mg/day). International prostate symptom score, quality of life, serum prostate specific antigen, prostate volume and maximal urinary flow rate were measured. In groups B, C and D, the international prostate symptom score were reduced by 3 months. Quality of life score was improved after 6 months in group D, while those of groups B and C were improved after 3 months, compared to the baseline value. Serum prostate specific antigen was reduced only in group D after 3 months, but no difference was observed in prostate volume in all treatment groups. Maximal urinary flow rate were gradually improved in groups B and C, with statistical significance after 6 months in group B and after 12 months in group C. None of the parameters were significantly improved by combined treatment with pumpkin seed oil and saw palmetto oil. From these results, it is suggested that administrations of pumpkin seed oil and saw palmetto oil are clinically safe and may be effective as complementary and alternative medicine treatments for benign prostatic hyperplasia.

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References

  1. Bach D (2000). Placebo-controlled, long-term therapeutic study of a pumpkin seed extract product in patients with micturition complaints from benign prostatic hyperplasia. Urologe B 40:437-443 https://doi.org/10.1007/s001310050432
  2. Barry MJ, Fowler FJ Jr., Bin L, Pitts JC 3rd, Harris CJ & Mulley AG Jr. (1997). The natural history of patients with benign prostatic hyperplasia as diagnosed by North American urologists. J Urol 157:10-14 https://doi.org/10.1016/S0022-5347(01)65267-4
  3. Braeckman J (1994). The extract of serenoa repens in the treatment of benign prostatic hyperplasia: A multicenter open study. Curr Ther Res 55:776-785 https://doi.org/10.1016/S0011-393X(05)80771-4
  4. Breu W, Hagenlocher M, Redl K, Tittel G, Stadler F & Wagner H (1992). Anti-inflammatory activity of sabal fruit extracts prepared with supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and 5-lipoxygenase metabolism. Arzneimittelforschung 42:547-551
  5. Buck AC (2004). Is there a scientific basis for the therapeutic effects of serenoa repens in benign prostatic hyperplasia? Mechanisms of action. J Urol 172:1792-1799 https://doi.org/10.1097/01.ju.0000140503.11467.8e
  6. Carbin BE, Larsson B & Lindahl O (1990). Treatment of benign prostatic hyperplasia with phytosterols. Br J Urol 66:639-641 https://doi.org/10.1111/j.1464-410X.1990.tb07199.x
  7. Carraro JC, Raynaud JP, Koch G, Chisholm GD, Di Silverio F, Teillac P, Da Silva FC, Cauquil J, Chopin DK, Hamdy FC, Hanus M, Hauri D, Kalinteris A, Marencak J, Perier A & Perrin P (1996). Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 29:231-240 https://doi.org/10.1002/(SICI)1097-0045(199610)29:4<231::AID-PROS4>3.0.CO;2-E
  8. Cho JS, Kim CI, Seong DH, Kim HS, Kim YS & Kim SJ (2005). Relationship between serum prostate specific antigen and prostate volume in men with benign prostatic hyperplasia from multicenter study. Korean Journal of Urology 46:792-798
  9. Cristoni A, Di Pierro F & Bombardelli E (2000). Botanical derivatives for the prostate. Fitoterapia 71:S21-28 https://doi.org/10.1016/S0367-326X(00)00174-X
  10. Debruyne F, Koch G, Boyle P, Da Silva FC, Gillenwater JG, Hamdy FC, Perrin P, Teillac P, Vela-Navarrete R & Raynaud JP (2002). Comparison of a phytotherapeutic agent (Permixon) with an alpha-blocker (Tamsulosin) in the treatment of benign prostatic hyperplasia: a 1-year randomized international study. Eur Urol 41:497-506 https://doi.org/10.1016/S0302-2838(02)00066-0
  11. Di Silverio F, D'Eramo G, Lubrano C, Flammia GP, Sciarra A, Palma E, Caponera M & Sciarra F (1992). Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 21:309-314 https://doi.org/10.1159/000474863
  12. Ernst E (2002). The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava. Ann Intern Med 136:42-53 https://doi.org/10.7326/0003-4819-136-1-200201010-00010
  13. Gossell-Williams M, Davis A & O'Connor N (2006). Inhibition of testosterone-induced hyperplasia of the prostate of sprague-dawley rats by pumpkin seed oil. J Med Food 9:284-286 https://doi.org/10.1089/jmf.2006.9.284
  14. Hirsch IH (2000). Integrative urology: a spectrum of complementary and alternative therapy. Urology 56:185-189 https://doi.org/10.1016/S0090-4295(00)00610-5
  15. Hisashi H, Masahiro N, Yoshifumi S, Kenichi T, Hiroshi K & Tsuneharu M (2005). Prevalence of lower urinary tract symptoms and seeking acupuncture treatment in men and women aged years or older: A community-based epidemiological study in Japan. Japanese Acupuncture and Moxibustion 1:27-35
  16. Kondas J, Philipp V & Dioszeghy G (1996). Sabal serrulata extract (Strogen forte) in the treatment of symptomatic benign prostatic hyperplasia. Int Urol Nephrol 28:767-772 https://doi.org/10.1007/BF02550725
  17. Lee DH, Yang WJ, Chung BH, Kim SI, Kim SJ & Kim HS (2005). A multicenter study of the detection rate for prostate cancer according to the serum prostate specific antigen level in Korean men. Korean Journal of Urology 46:433-437
  18. Lee S, Min HG, Choi SH, Kim YJ, Oh SW, Park Y & Kim SS (2006). Central obesity as a risk factor for prostatic hyperplasia. Obesity (Silver Spring) 14:172-179 https://doi.org/10.1038/oby.2006.21
  19. Marks LS, Partin AW, Epstein JI, Tyler VE, Simon I, Macairan ML, Chan TL, Dorey FJ, Garris JB, Veltri RW, Santos PB, Stonebrook KA & deKernion JB (2000). Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 163:1451-1456 https://doi.org/10.1016/S0022-5347(05)67641-0
  20. Mehrabi S, Shirazi HG, Rastim M & Bayat B (2005). Analysis of serum prostate-specific antigen levels in men aged 40 years and older in yasuj, Iran. Urol J 2:189-192
  21. Melo EA, Bertero EB, Rios LA & Mattos D Jr. (2002). Evaluating the efficiency of a combination of Pygeum africanum and stinging nettle (Urtica dioica) extracts in treating benign prostatic hyperplasia (BPH): double-blind, randomized, placebo controlled trial. Int Braz J Urol 28:418-425
  22. Moon YT, Oh CH & Kim SC (1990). Clinical effect of Sitosterol ($Pronal^{R}$) on the treatment of benign prostatic hypertrophy. Korean Journal of Andrology 8:23-29
  23. Nickel JC (1998). Placebo therapy of benign prostatic hyperplasia: a 25-month study. Canadian PROSPECT Study Group. Br J Urol 81:383-387 https://doi.org/10.1046/j.1464-410x.1998.00554.x
  24. Ortiz MV (1998). Alternative medicine: Incorporation into therapeutics topics. Am J Pharm Educ 62:208-212
  25. Pathak SK, Sharma RA & Mellon JK (2003). Chemoprevention of prostate cancer by diet-derived antioxidant agents and hormonal manipulation (Review). Int J Oncol 22:5-13
  26. Preuss HG, Marcusen C, Regan J, Klimberg IW, Welebir TA & Jones WA (2001). Randomized trial of a combination of natural products (cernitin, saw palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH). Int Urol Nephrol 33:217-225 https://doi.org/10.1023/A:1015227604041
  27. Shoskes DA (2002). Phytotherapy in chronic prostatitis. Urology 60:35-37 https://doi.org/10.1016/S0090-4295(02)02383-X
  28. Singh YN, Devkota AK, Sneeden DC, Singh KK & Halaweish F (2007). Hepatotoxicity potential of saw palmetto (Serenoa repens) in rats. Phytomedicine 14:204-208 https://doi.org/10.1016/j.phymed.2006.03.024
  29. Tsai YS, Tong YC, Cheng JT, Lee CH, Yang FS & Lee HY (2006). Pumpkin seed oil and phytosterol-F can block testosterone/prazosin-induced prostate growth in rats. Urol Int 77:269-274 https://doi.org/10.1159/000094821
  30. Vickers A (2000). Recent advances: complementary medicine. BMJ 321:683-686 https://doi.org/10.1136/bmj.321.7262.683
  31. Watson V, Ryan M, Brown CT, Barnett G, Ellis BW & Emberton M (2004). Eliciting preferences for drug treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. J Urol 172:2321-2325 https://doi.org/10.1097/01.ju.0000140957.31325.7f
  32. Weisser H, Tunn S, Behnke B & Krieg M (1996). Effects of the Sabal serrulata extract IDS 89 and its subfraction on 5 alpha-reductase activity in human benign prostatic hyperplasia. Prostate 28:300-306 https://doi.org/10.1002/(SICI)1097-0045(199605)28:5<300::AID-PROS5>3.0.CO;2-F
  33. Willetts KE, Clements MS, Champion S, Ehsman S & Eden JA (2003). Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trial. BJU Int 92:267-270 https://doi.org/10.1046/j.1464-410X.2003.04316.x
  34. Wilt TJ, Ishani A, Rutks I & MacDonald R (2000). Phytotherapy for benign prostatic hyperplasia. Public Health Nutr 3:459-472 https://doi.org/10.1017/S1368980000000549
  35. Wilt TJ, Ishani A, Stark G, MacDonald R, Lau J & Mulrow C (1998). Saw Palmetto extracts for treatment of benign prostatic hyperplasia. JAMA 280:1604-1609 https://doi.org/10.1001/jama.280.18.1604
  36. Wilt TJ, MacDonald R & Ishani A (1999). beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 83:976-983
  37. Zhang W, Wang X, Liu Y, Tian H, Flickinger B, Empie MW & Sun SZ (2008). Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia. J Med Food 11:207-214 https://doi.org/10.1089/jmf.2007.602

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