The Korean Journal of Physiology and Pharmacology

  • 제13권6호
  • /
  • Pages.431-436
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  • 2009
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase

  • Lee, Kwon-Ho (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Lee, Sang-Ki (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Kim, Hyo-Shin (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Cho, Eun-Jung (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Joo, Hee-Kyoung (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Lee, Eun-Ji (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Lee, Ji-Young (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Park, Myoung-Soo (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Chang, Seok-Jong (Department of Physiology, College of Medicine, Seonam University) ;
  • Cho, Chung-Hyun (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Park, Jin-Bong (Department of Physiology, School of Medicine, Chungnam National University) ;
  • Jeon, Byeong-Hwa (Department of Physiology, School of Medicine, Chungnam National University)
  • 발행 : 2009.12.31
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초록

The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Pb exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells.

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참고문헌

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